Yousuf Abdilahi, Mohd Arifin Siti Roshaidai, Musa Ramli, Md Isa Muhammad Lokman
College of Medicine and Health Sciences, Jijiga University , Jijiga, Ethiopia.
Kulliyah of Nursing, IIUM, Malaysia.
Clin Pract Epidemiol Ment Health. 2019 Dec 31;15:153-159. doi: 10.2174/1745017901915010153. eCollection 2019.
Depression is the most common mental disorder and a leading cause of disability, which commonly presents unexplained psychological and physical symptoms. Depression and HIV/AIDS are commonly comorbid. This review provides an insight into the effect of depression on disease progression among people living with HIV.
A search for relevant articles was conducted using a database like MEDLINE, Scopus, PsycINFO and CINAHL. Peer-reviewed English journals published between 2015 and 2019 were included in the review.
A total of eight studies conducted in different settings were included in the review. This review has found that psychosocial, neurohormonal and virologic factors associated with depression affect HIV disease progression. Yet, the chronicity of depression, absence of the hormones that have a buffer effect on depression and lack of examination if depression is a predictor, or an outcome of disease progression, were some of the gaps that require further investigation.
Considerably, more research is needed to better understand the effect of mental disorder, especially depression, on HIV disease progression to AIDS and future interventions should, therefore, concentrate on the integration of mental health screening in HIV clinical setup.
抑郁症是最常见的精神障碍，也是导致残疾的主要原因，通常表现为无法解释的心理和身体症状。抑郁症与艾滋病毒/艾滋病常合并存在。本综述深入探讨了抑郁症对艾滋病毒感染者疾病进展的影响。
使用MEDLINE、Scopus、PsycINFO和CINAHL等数据库搜索相关文章。纳入2015年至2019年间发表的经过同行评审的英文期刊。
该综述共纳入了八项在不同环境下进行的研究。本综述发现，与抑郁症相关的心理社会、神经激素和病毒学因素会影响艾滋病毒疾病的进展。然而，抑郁症的慢性病程、缺乏对抑郁症有缓冲作用的激素，以及未考察抑郁症是否是疾病进展的预测因素或结果，这些都是需要进一步研究的空白。
显然，需要更多的研究来更好地理解精神障碍，尤其是抑郁症，对艾滋病毒疾病进展为艾滋病的影响，因此未来的干预措施应集中于在艾滋病毒临床环境中整合心理健康筛查。
