剖宫产在儿童哮喘中的作用。
The role of Caesarean section in childhood asthma.
作者信息
Al Yassen A Q, Al-Asadi J N, Khalaf S K
机构信息
FRACGP College of Medicine, Basrah University, Iraq E-mail:
M.Sc. College of Medicine, Basrah University, Iraq E-mail:
出版信息
Malays Fam Physician. 2019 Dec 31;14(3):10-17. eCollection 2019.
OBJECTIVE
As indicated by previous studies, children born via Caesarean section may have an increased risk of developing asthma compared with those born via vaginal delivery. The aim of this study is to assess the association between a Caesarean section and the risk of childhood asthma. This was a case-control study carried out in Basrah, Iraq including 952 children aged 3-12 years. Four hundred and seven asthmatic cases and a control group of 545 age-matched non-asthmatic children were enrolled. Binary logistic regression was used to assess the relationship between asthma and birth via Caesarean section.
RESULTS
The mean age of the children was 6.7±2.5 years. Two-hundred eighty-three children (29.7%) were delivered via Caesarean section. The binary logistic regression analysis showed that delivery via Caesarean section was found to be an independent significant risk factor for asthma (OR=3.37; 95% CI=1.76-6.46; p<0.001). In addition, many other risk factors were found to be significant predictors of asthma, including bottlefeeding (OR=27.29; 95% CI=13.54-54.99; p<0.001) and low birth weight (OR=16.7; 95% CI=6.97-37.49; p<0.001).
CONCLUSION
Caesarean section is significantly associated with an increased risk of childhood asthma.
目的
既往研究表明，与经阴道分娩的儿童相比，剖宫产出生的儿童患哮喘的风险可能更高。本研究旨在评估剖宫产与儿童哮喘风险之间的关联。这是一项在伊拉克巴士拉开展的病例对照研究，纳入了952名3至12岁的儿童。其中有407例哮喘病例以及一个由545名年龄匹配的非哮喘儿童组成的对照组。采用二元逻辑回归分析来评估哮喘与剖宫产出生之间的关系。
结果
儿童的平均年龄为6.7±2.5岁。283名儿童（29.7%）通过剖宫产出生。二元逻辑回归分析显示，剖宫产被发现是哮喘的一个独立显著危险因素（比值比=3.37；95%置信区间=1.76 - 6.46；p<0.001）。此外，还发现许多其他危险因素是哮喘的显著预测因素，包括奶瓶喂养（比值比=27.29；95%置信区间=13.54 - 54.99；p<0.001）和低出生体重（比值比=16.7；95%置信区间=6.97 - 37.49；p<0.001）。
结论
剖宫产与儿童哮喘风险增加显著相关。
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