僵人综合征：两例僵人综合征罕见病例
The Stiff People: Two Rare Cases of Stiff-person Syndrome.
作者信息
Siddiqui Muhammad Z, Tohid Hassaan, Brown Rebecca, Qazi Samia
机构信息
Internal Medicine, Nassau University Medical Center, East Meadow, USA.
Research, California Instititute of Behavioral Neurosciences and Psychology, Fairfield, USA.
出版信息
Cureus. 2017 Aug 23;9(8):e1602. doi: 10.7759/cureus.1602.
Stiff-person syndrome (SPS) is a rare disorder that affects the central nervous system and is characterized by progressive muscle stiffness, rigidity, and spasm of axial and limb muscles. The syndrome is caused by a lack of gamma aminobutyric acid (GABA), which occurs because of antibodies against glutamic acid decarboxylase (GAD), an essential enzyme for GABA synthesis. Hence, the patients present with increased muscular activity. In this article, we will discuss two case studies of stiff-person syndrome.
僵人综合征（SPS）是一种影响中枢神经系统的罕见疾病，其特征为轴向和肢体肌肉进行性僵硬、强直及痉挛。该综合征由γ-氨基丁酸（GABA）缺乏引起，而这是由于针对谷氨酸脱羧酶（GAD，GABA合成的关键酶）的抗体所致。因此，患者表现出肌肉活动增加。在本文中，我们将讨论两例僵人综合征的病例研究。
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