Huang Xuan, Zhang Tian-Ze, Li Guang-Hua, Liu Lei, Xu Guang-Quan
Department of Thoracic Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Medicine (Baltimore). 2020 Mar;99(11):e19087. doi: 10.1097/MD.0000000000019087.
Identify the prevalence of postoperative anxiety and depression as well as their correlations with clinical features and survival profiles in non-small-cell lung cancer (NSCLC) patients who underwent resection.Four hundred NSCLC patients who underwent resection were recruited, and their anxiety and depression were assessed by hospital anxiety and depression scale (HADS) at discharge after surgery. Besides, 480 healthy controls (HCs) were also enrolled and assessed by HADS.The HADS-Anxiety score of NSCLC patients (7.8 ± 3.9) was greatly higher than that of HCs (4.8 ± 2.7), and the anxiety prevalence of NSCLC patients (49.6%) were dramatically increased compared with HCs (13.8%). Furthermore, the HADS-Depression score (7.2 ± 3.6) of NSCLC patients was considerably increased compared with HCs (4.2 ± 2.6), and the depression prevalence of NSCLC patients (38.3%) was significantly raised compared with HCs (10.0%). Besides, anxiety correlated with gender, marital status, hypertension, diabetes, pathological differentiation, tumor size, lymph node metastasis, TNM stage and carcinoembryonic antigen level, meanwhile, depression correlated with marital status, employment status before surgery, diabetes, pathological differentiation, and TNM stage in NSCLC patients. Additionally, the anxiety and depression predicted shorter disease-free survival in NSCLC patients. And the anxiety predicted worse overall survival (OS), while no association of depression with OS was observed in NSCLC patients.Post-operative anxiety and depression are highly prevalent and implicated in the ongoing care and prognosis prediction in NSCLC patients who underwent resection.
确定接受手术切除的非小细胞肺癌（NSCLC）患者术后焦虑和抑郁的患病率，以及它们与临床特征和生存情况的相关性。招募了400例接受手术切除的NSCLC患者，并在术后出院时采用医院焦虑抑郁量表（HADS）对其焦虑和抑郁情况进行评估。此外，还纳入了480名健康对照者（HCs），并采用HADS对其进行评估。NSCLC患者的HADS焦虑评分（7.8±3.9）显著高于HCs（4.8±2.7），NSCLC患者的焦虑患病率（49.6%）与HCs（13.8%）相比显著升高。此外，NSCLC患者的HADS抑郁评分（7.2±3.6）与HCs（4.2±2.6）相比明显升高，NSCLC患者的抑郁患病率（38.3%）与HCs（10.0%）相比显著升高。此外，在NSCLC患者中，焦虑与性别、婚姻状况、高血压、糖尿病、病理分化、肿瘤大小、淋巴结转移、TNM分期和癌胚抗原水平相关，同时，抑郁与婚姻状况、术前就业状况、糖尿病、病理分化和TNM分期相关。此外，焦虑和抑郁预示着NSCLC患者无病生存期较短。焦虑预示着总生存期（OS）较差，而在NSCLC患者中未观察到抑郁与OS的关联。术后焦虑和抑郁在接受手术切除的NSCLC患者的持续护理和预后预测中高度普遍且具有重要意义。
