血清肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6 和白细胞介素-17 在一定程度上与非小细胞肺癌幸存者的焦虑和抑郁风险有关。
Serum tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-17 relate to anxiety and depression risks to some extent in non-small cell lung cancer survivor.
机构信息
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
出版信息
Clin Respir J. 2022 Feb;16(2):105-115. doi: 10.1111/crj.13457. Epub 2021 Nov 9.
INTRODUCTION
Inflammatory cytokines are proposed as modulators for the pathogenesis of anxiety and depression (anxiety/depression), and anxiety/depression are frequently existed in non-small cell lung cancer (NSCLC) survivors. However, no published study has explored the association of inflammation cytokines with anxiety/depression in NSCLC survivors.
OBJECTIVES
We aimed to evaluate serum tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-17 (IL-17) levels, and their correlations with anxiety/depression in NSCLC survivors.
METHODS
Totally, 217 NSCLC survivors and 200 controls were recruited. Then, inflammatory cytokines in serum samples were detected by enzyme-linked immunosorbent assay (ELISA). Besides, their anxiety/depression status was assessed by Hospital Anxiety and Depression Scale (HADS).
RESULTS
HADS-anxiety score, anxiety rate, anxiety severity, HADS-depression score, depression rate, and depression severity were all increased in NSCLC survivors compared with controls (all P < 0.001). Regarding inflammatory cytokines, TNF-α, IL-1β, and IL-17 levels were higher (all P < 0.01), while IL-6 (P = 0.105) level was of no difference in NSCLC survivors compared with controls. Furthermore, TNF-α, IL-1β, IL-6, and IL-17 were all positively associated with HADS-A score (all P < 0.05), anxiety occurrence (all P < 0.05), HADS-D score (all P < 0.05), and depression occurrence (all P < 0.05) in NSCLC survivors, while the correlation-coefficients were weak. Additionally, multivariate logistic regression analyses disclosed that TNF-α (both P < 0.05) and IL-1β (both P < 0.001) were independently correlated with increased anxiety and depression risks in NSCLC survivors.
CONCLUSION
Serum TNF-α, IL-1β, IL-6, and IL-17 are related to increased anxiety and depression risks to some extent in NSCLC survivors.
简介
炎症细胞因子被认为是焦虑和抑郁（焦虑/抑郁）发病机制的调节剂，而焦虑/抑郁在非小细胞肺癌（NSCLC）幸存者中经常出现。然而，目前尚无研究探讨炎症细胞因子与 NSCLC 幸存者焦虑/抑郁之间的关系。
目的
本研究旨在评估 NSCLC 幸存者血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和白细胞介素-17（IL-17）水平及其与焦虑/抑郁的相关性。
方法
共纳入 217 名 NSCLC 幸存者和 200 名对照者。采用酶联免疫吸附试验（ELISA）检测血清炎症细胞因子水平，同时采用医院焦虑抑郁量表（HADS）评估焦虑/抑郁状况。
结果
与对照组相比，NSCLC 幸存者的 HADS 焦虑评分、焦虑发生率、焦虑严重程度、HADS 抑郁评分、抑郁发生率和抑郁严重程度均升高（均 P<0.001）。在炎症细胞因子方面，与对照组相比，TNF-α、IL-1β 和 IL-17 水平升高（均 P<0.01），而 IL-6 水平差异无统计学意义（P=0.105）。此外，TNF-α、IL-1β、IL-6 和 IL-17 与 NSCLC 幸存者的 HADS-A 评分（均 P<0.05）、焦虑发生率（均 P<0.05）、HADS-D 评分（均 P<0.05）和抑郁发生率（均 P<0.05）均呈正相关，但其相关系数较弱。此外，多变量逻辑回归分析显示，TNF-α（均 P<0.05）和 IL-1β（均 P<0.001）与 NSCLC 幸存者焦虑和抑郁风险增加独立相关。
结论
血清 TNF-α、IL-1β、IL-6 和 IL-17 与 NSCLC 幸存者的焦虑和抑郁风险增加有一定的相关性。
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