Liu Jianmin, Wang Yongkuan, Liu Sisi, Cao Shuwei, Xu Chunyan, Zhang Meng, Liu Shixi
Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan.
Department of Otolaryngology, Head and Neck Surgery, People's Hospital of De Yang City, De Yang.
Medicine (Baltimore). 2020 Mar;99(11):e19497. doi: 10.1097/MD.0000000000019497.
Allergic rhinitis (AR) is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence of AR is increasing, resulting in a large social burden. Importantly, the impact of air pollution on health is a widespread concern. We aim to evaluate association of air pollution and AR risk.
This prospective study includes patients undergoing AR. The exclusion criteria will be as follows: Patients with nasal infection, nasal polyps, nasal tumors, mental disorders, and immunodeficiency will be excluded. Air pollution levels of ambient air pollutants including PM2.5, PM10, sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon dioxide (CO), and O3, and patient data will be collected. The correlation analysis will be performed in air pollutants and AR risk.
This study will provide correlation of NO2, SO2, PM10, and PM2.5 for AR in several aspects, including symptom score, drug score, quality of life score, asthma control score, side effects, and laboratory examination such as nasal function test, serum total immunoglobulin E, and nasal secretion smear.
变应性鼻炎（AR）是一种主要的慢性呼吸道炎症性疾病。大量的流行病学调查表明，AR的患病率正在上升，导致了巨大的社会负担。重要的是，空气污染对健康的影响是一个广泛关注的问题。我们旨在评估空气污染与AR风险之间的关联。
这项前瞻性研究纳入了AR患者。排除标准如下：患有鼻腔感染、鼻息肉、鼻肿瘤、精神障碍和免疫缺陷的患者将被排除。将收集包括PM2.5、PM10、二氧化硫（SO2）、二氧化氮（NO2）、二氧化碳（CO）和臭氧（O3）在内的环境空气污染物的污染水平以及患者数据。将对空气污染物与AR风险进行相关性分析。
本研究将在多个方面提供NO2、SO2、PM10和PM2.5与AR的相关性，包括症状评分、药物评分、生活质量评分、哮喘控制评分、副作用以及实验室检查，如鼻功能测试、血清总免疫球蛋白E和鼻分泌物涂片。
