From the Departments of Radiology and Nuclear Medicine.
J Comput Assist Tomogr. 2021;45(1):103-109. doi: 10.1097/RCT.0000000000000981.
We compared 40- to 70-keV virtual monoenergetic to conventional computed tomography (CT) perfusion reconstructions with respect to quality of perfusion maps.
Conventional CT perfusion (CTP) images were acquired at 80 kVp in 25 patients, and 40- to 70-keV images were acquired with a dual-layer CT at 120 kVp in 25 patients. First, time-attenuation-curve contrast-to-noise ratio was assessed. Second, the perfusion maps of both groups were qualitatively analyzed by observers. Last, the monoenergetic reconstruction with the highest quality was compared with the clinical standard 80-kVp CTP acquisitions.
Contrast-to-noise ratio was significantly better for 40 to 60 keV as compared with 70 keV and conventional images (P < 0.001). Visually, the difference between the blood volume maps among reconstructions was minimal. The 50-keV perfusion maps had the highest quality compared with the other monoenergetic and conventional maps (P < 0.002).
The quality of 50-keV CTP images is superior to the quality of conventional 80- and 120-kVp images.
我们比较了 40 至 70keV 虚拟单能量与常规 CT 灌注重建在灌注图质量方面的差异。
25 例患者在 80kVp 下采集常规 CT 灌注（CTP）图像，25 例患者在 120kVp 下采集双层 CT 的 40 至 70keV 图像。首先，评估时间衰减曲线的对比噪声比。其次，观察者对两组灌注图进行定性分析。最后，将质量最高的单能量重建与临床标准 80kVp CTP 采集进行比较。
与 70keV 和常规图像相比，40 至 60keV 的对比噪声比显著更好（P < 0.001）。从视觉上看，重建之间的血容量图之间的差异最小。与其他单能量和常规图像相比，50keV 灌注图的质量最高（P < 0.002）。
50keV CTP 图像的质量优于常规 80 和 120kVp 图像的质量。
