Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju; Department of Medicine, Graduate School of Medicine, Yonsei University, Seoul, Republic of Korea. .
Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
J Gastrointestin Liver Dis. 2020 Mar 13;29(1):59-64. doi: 10.15403/jgld-713.
Nonalcoholic fatty liver disease (NAFLD) is clinically important because of its association with an increased risk of sudden cardiac death as well as liver-related mortality. Most cases of sudden cardiac death could be mediated by an arrhythmogenic process. Thus, we aimed to determine the association between NAFLD and corrected QT (QTc) interval in apparently healthy Korean women.
This cross-sectional study included 764 women aged 20 to 74 years old who underwent a health examination program between 2014 and 2015. The QTc interval was calculated using Bazett's formula (QTc = QT/√RR). Multiple linear and logistic regression analysis were performed to assess independent relationships between NAFLD and QTc interval and prolonged QTc (≥ 450 milliseconds) was calculated after adjusting for confounding variables.
The overall prevalence of NAFLD was 23.5% in general healthy women. The standardized β coefficient (95% confidence interval) of the QTc increment in patients with NAFLD was 6.4 milliseconds (1.2-11.8) through multiple linear regression analysis after adjusting for age, body mass index, smoking status, and regular exercise as well as mean arterial pressure, fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, aspartate aminotransferase, alanine aminotransferase, calcium, potassium levels and menopause status. Similarly, the odds ratio (95% confidence interval) of NAFLD for prolonged QTc was 2.05 (1.13-3.71) according to multiple logistic regression analysis after adjusting for the same covariables in women aged 20 to 74 years old.
We demonstrated the arrhythmogenic potential of NAFLD, implying that careful monitoring of patient electrocardiograms is necessary to evaluate the possible arrhythmic risk in general healthy women with NAFLD.
非酒精性脂肪性肝病（NAFLD）与心脏性猝死风险增加以及与肝脏相关的死亡率相关，因此具有重要的临床意义。大多数心脏性猝死病例可能由心律失常过程介导。因此，我们旨在确定非酒精性脂肪性肝病与明显健康的韩国女性校正 QT（QTc）间期之间的关联。
本横断面研究纳入了 764 名年龄在 20 至 74 岁之间于 2014 年至 2015 年期间接受健康体检计划的女性。使用 Bazett 公式（QTc = QT/√RR）计算 QTc 间期。进行多元线性和逻辑回归分析，以评估 NAFLD 与 QTc 间期之间的独立关系，并在调整混杂变量后计算延长的 QTc（≥450 毫秒）。
一般健康女性中 NAFLD 的总体患病率为 23.5%。通过多元线性回归分析，在调整年龄、体重指数、吸烟状况和定期运动以及平均动脉压、空腹血糖、甘油三酯、高密度脂蛋白胆固醇、天冬氨酸转氨酶、丙氨酸转氨酶、钙、钾水平和绝经状态后，NAFLD 患者的 QTc 增加的标准化β系数（95%置信区间）为 6.4 毫秒（1.2-11.8）。同样，根据多元逻辑回归分析，在 20 至 74 岁的女性中调整相同的协变量后，NAFLD 发生延长 QTc 的比值比（95%置信区间）为 2.05（1.13-3.71）。
我们证明了 NAFLD 的致心律失常潜力，这意味着在一般健康的 NAFLD 女性中，需要仔细监测患者的心电图，以评估可能的心律失常风险。
