Department of Medicine, USERN Office, Fasa University of Medical Sciences, Fasa, Iran.
Noncommunicable Diseases Research Center, Fasa University of Medical Science, Fasa, Iran.
Clin Cardiol. 2023 Jun;46(6):615-621. doi: 10.1002/clc.24015. Epub 2023 Apr 4.
There are limited studies about the association between nonalcoholic fatty liver disease (NAFLD) and corrected QT interval (QTc) prolongation worldwide.
Therefore, we designed the current study to determine this association in a large cohort of a generally healthy population.
We analyzed the data of 4603 individuals aged 35-70 who participated in the Fasa Cohort Study (FACS). Based on 12-lead electrocardiograms, QT intervals were calculated and corrected by Bazzet's formula. A QTc interval of more than 430 ms in men and 450 ms in women was considered prolonged. The Fatty Liver Index was used to identify the participants with NAFLD.
Of all participants, 1550 (33.6%) met the NAFLD criteria. In subjects of both genders with NAFLD, the mean values of the QTc interval were considerably higher than in those without NAFLD (p < .001). After adjusting for a wide range of confounders, including age, gender, smoking status, physical activity, total cholesterol, high-density lipoprotein-cholesterol levels, diabetes, and hypertension status, in linear regression analysis, the standardized β coefficient of QTc interval among participants with NAFLD was 2.56 ms (95% confidence interval [CI]: 0.49-4.64). After controlling the same confounders, the odds ratio of NAFLD for a prolonged QTc interval in men was 1.47 (95% CI: 1.18-1.84; p < .001) and in women was 1.39 (95% CI: 1.15-1.68; p < .001) using logistic regression analysis.
NAFLD was a risk factor for QTc interval prolongation. Awareness about the risk of NAFLD in increasing the potential cardiac arrhythmias should be raised to lower cardiac mortality.
全球范围内，关于非酒精性脂肪性肝病（NAFLD）与校正 QT 间期（QTc）延长之间的关联，研究有限。
因此，我们设计了本项研究，以在一个通常健康的人群大队列中确定这种关联。
我们分析了参加法萨队列研究（Fasa Cohort Study，FACS）的 4603 名年龄在 35-70 岁之间个体的数据。基于 12 导联心电图，通过 Bazett 公式计算并校正 QT 间期。男性 QTc 间期超过 430 ms，女性超过 450 ms 被认为是延长的。使用脂肪肝指数来识别患有 NAFLD 的参与者。
所有参与者中，有 1550 名（33.6%）符合 NAFLD 标准。在患有和不患有 NAFLD 的男女受试者中，QTc 间期的平均值明显更高（p <.001）。在校正了包括年龄、性别、吸烟状况、体力活动、总胆固醇、高密度脂蛋白胆固醇水平、糖尿病和高血压状态在内的广泛混杂因素后，在线性回归分析中，患有 NAFLD 的参与者的 QTc 间期标准化β系数为 2.56 ms（95%置信区间[CI]：0.49-4.64）。在校正相同混杂因素后，男性中，NAFLD 与 QTc 间期延长的比值比（odds ratio，OR）为 1.47（95% CI：1.18-1.84；p <.001），女性为 1.39（95% CI：1.15-1.68；p <.001），采用 logistic 回归分析。
NAFLD 是 QTc 间期延长的一个危险因素。应该提高对 NAFLD 增加潜在心律失常风险的认识，以降低心脏死亡率。
