Chou Chia-Huei, Lai Yi-Ru, Chi Chih-Yu, Ho Mao-Wang, Chen Chao-Ling, Liao Wei-Chih, Ho Cheng-Mao, Chen Yu-An, Chen Chih-Yu, Lin Yu-Tzu, Lin Chia-Der, Lai Chih-Ho
Departments of Infectious Disease, China Medical University Hospital, Taichung 40447, Taiwan.
School of Medicine, Department of Medical Laboratory Science and Biotechnology, Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Microorganisms. 2020 Mar 12;8(3):397. doi: 10.3390/microorganisms8030397.
The increasing emergence of multidrug-resistant (MDR) bacteria has been recognized as a public health threat worldwide. Hospitalized patients and outpatients are commonly infected by non-fermenting Gram-negative bacilli (NFGNB), particularly the - complex (ACB) and . Antimicrobial agents are critical for treating the nosocomial infections caused by NFGNB. The aim of this study was to assess antimicrobial resistance and the use of antimicrobial agents. The bacterial isolates of 638,152 specimens from both inpatients and outpatients, retrieved from 2001 to 2008 at a medical center in central Taiwan, were examined for their susceptibility to various antimicrobial agents, including cefepime, imipenem, ciprofloxacin, gentamicin, amikacin, meropenem, and levofloxacin. Administrated prescriptions of the monitored antibiotics were analyzed using the Taiwan National Health Insurance Research Database (NHIRD). Our results show that the defined daily doses (DDDs) for cefepime, imipenem, and ciprofloxacin increased with time, and a trend toward reduced antimicrobial sensitivities of both ACB and was noticeable. In conclusion, the antimicrobial sensitivities of ACB and were reduced with the increased use of antibiotics. Continuous surveillance of antibiotic prescriptions and the prevalence of emerging resistance in nosocomial infections is warranted.
多重耐药（MDR）细菌的不断出现已被公认为是全球公共卫生威胁。住院患者和门诊患者通常会被非发酵革兰氏阴性杆菌（NFGNB）感染，尤其是嗜麦芽窄食单胞菌复合群（ACB）和鲍曼不动杆菌。抗菌药物对于治疗由NFGNB引起的医院感染至关重要。本研究的目的是评估抗菌药物耐药性以及抗菌药物的使用情况。对2001年至2008年在台湾中部一家医疗中心采集的638,152份住院患者和门诊患者标本的细菌分离株进行检测，以确定它们对各种抗菌药物的敏感性，这些抗菌药物包括头孢吡肟、亚胺培南、环丙沙星、庆大霉素、阿米卡星、美罗培南和左氧氟沙星。使用台湾国民健康保险研究数据库（NHIRD）分析所监测抗生素的给药处方。我们的结果表明，头孢吡肟、亚胺培南和环丙沙星的限定日剂量（DDDs）随时间增加，并且ACB和鲍曼不动杆菌的抗菌敏感性均有降低的趋势。总之，随着抗生素使用的增加，ACB和鲍曼不动杆菌的抗菌敏感性降低。有必要持续监测抗生素处方以及医院感染中新兴耐药性的流行情况。
