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回肠造口术逆转后的艰难梭菌感染

Clostridium difficile Infection After Ileostomy Reversal.

作者信息

Kim Ho Seung, Kang Jae Hyun, Kim Han-Gil, Kim Young Hun, Bae Hyeonwoo, Kim Nam Kyu

机构信息

Division of Colorectal Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Ann Coloproctol. 2021 Jul;37(Suppl 1):S4-S6. doi: 10.3393/ac.2019.09.24. Epub 2020 Mar 16.

DOI:10.3393/ac.2019.09.24
PMID:32178491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8359696/
Abstract

Clostridium difficile infection (CDI) after ileostomy reversal is rare, with few reports available in the available literature describing this condition. The diagnosis of CDI after ileostomy reversal is challenging because symptoms such as diarrhea observed in these patients can occur frequently after surgery. However, CDI can be fatal, so early diagnosis and prompt treatment are important. We discuss 2 patients with positive C. difficile toxin assay results on stool cultures performed after ileostomy reversal. Clinical progression differed between these patients: one patient who presented with severe CDI and shock was successfully treated following a prolonged intensive care unit stay for the management of vital signs and underwent hemodialysis, while another patient showed symptoms of mild colitis but we could not confirm whether diarrhea was associated with CDI or with the usual postoperative state. To our knowledge, these represent 2 of just a few cases reported in the literature describing CDI after ileostomy reversal.

摘要

回肠造口术逆转后发生艰难梭菌感染(CDI)很罕见,现有文献中关于这种情况的报道很少。回肠造口术逆转后CDI的诊断具有挑战性,因为这些患者出现的腹泻等症状在术后可能经常发生。然而,CDI可能是致命的,所以早期诊断和及时治疗很重要。我们讨论2例在回肠造口术逆转后进行的粪便培养中艰难梭菌毒素检测结果呈阳性的患者。这两名患者的临床病程有所不同:一名出现严重CDI和休克的患者在重症监护病房长时间住院以维持生命体征并接受血液透析后成功治愈,而另一名患者表现出轻度结肠炎症状,但我们无法确定腹泻是与CDI有关还是与通常的术后状态有关。据我们所知,这是文献中报道的回肠造口术逆转后CDI的少数病例中的2例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09d6/8359696/93541816bdd1/ac-2019-09-24f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09d6/8359696/93541816bdd1/ac-2019-09-24f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09d6/8359696/93541816bdd1/ac-2019-09-24f1.jpg

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本文引用的文献

1
The role of single-shot metronidazole in the prevention of Clostridium difficile infection following ileostomy reversal surgery.单次服用甲硝唑在回肠造口术逆转手术后预防艰难梭菌感染中的作用。
Int J Colorectal Dis. 2017 May;32(5):733-736. doi: 10.1007/s00384-016-2725-0. Epub 2016 Nov 23.
2
Overwhelming Recurrent Clostridium difficile Infection after Reversal of Diverting Loop Ileostomy Created for Prior Fulminant C. difficile Colitis.为先前暴发性艰难梭菌结肠炎行转流性袢状回肠造口术后出现的难治性复发性艰难梭菌感染
Am Surg. 2016 Aug;82(8):e194-5.
3
Chronic inflammation masquerading as an appendiceal tumour with peritoneal metastasis: the challenge of diagnosis and the lessons learnt.
伪装成伴有腹膜转移的阑尾肿瘤的慢性炎症:诊断的挑战与经验教训
BMJ Case Rep. 2016 Feb 25;2016:bcr2015213911. doi: 10.1136/bcr-2015-213911.
4
Colonization with toxinogenic C. difficile upon hospital admission, and risk of infection: a systematic review and meta-analysis.入院时产毒艰难梭菌定植与感染风险:系统评价和荟萃分析。
Am J Gastroenterol. 2015 Mar;110(3):381-90; quiz 391. doi: 10.1038/ajg.2015.22. Epub 2015 Mar 3.
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World J Gastrointest Surg. 2014 Sep 27;6(9):169-74. doi: 10.4240/wjgs.v6.i9.169.
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Acute fulminant pseudomembranous colitis which developed after ileostomy closure and required emergent total colectomy: a case report.回肠造口关闭术后发生的急性暴发性假膜性结肠炎并需急诊行全结肠切除术:一例报告
J Med Case Rep. 2012 May 14;6:130. doi: 10.1186/1752-1947-6-130.
7
Prevalence of clostridium difficile in excluded colons.艰难梭菌在切除结肠中的患病率。
Am Surg. 2012 Apr;78(4):408-13.
8
Host and pathogen factors for Clostridium difficile infection and colonization.艰难梭菌感染和定植的宿主和病原体因素。
N Engl J Med. 2011 Nov 3;365(18):1693-703. doi: 10.1056/NEJMoa1012413.
9
Is Clostridium difficile infection a particular problem after reversal of ileostomy?艰难梭菌感染在回肠造口术后逆转后是一个特殊问题吗?
Colorectal Dis. 2011 Mar;13(3):308-11. doi: 10.1111/j.1463-1318.2009.02139.x.
10
Fulminant Clostridium difficile-associated pouchitis with a fatal outcome.暴发性艰难梭菌相关性袋炎并导致致命后果。
Nat Rev Gastroenterol Hepatol. 2009 Aug;6(8):492-5. doi: 10.1038/nrgastro.2009.105.