Department of Haematology, Faculty of Medicine, Ankara University, Ankara, Turkey
Department of Medical Biochemistry, Faculty of Medicine, Ankara University, Ankara, Turkey
Turk J Med Sci. 2020 Jun 23;50(4):798-803. doi: 10.3906/sag-1912-242.
BACKGROUND/AIM: Immune thrombocytopenia (ITP) is treated by corticosteroids and/or intravenous immune globulin as the first line treatment when necessary. Mean platelet volume (MPV) is a marker of platelet production and function. In this study, we aimed to search the relationship between the MPV and the treatment response in ITP patients and it was hypothesized that MPV can be used as a predictor of the response.
The 70 newly diagnosed adult primary ITP patients and 70 of healthy people were included. MPV between ITP and healthy population, MPV in the diagnosis and after the treatment between the responders and the nonresponders were compared.
The responders had significantly higher MPV and the nonresponders had significantly lower MPV than the healthy population (11.09 and 10.21 fL, P = 0.03; 9.38 and 10.21 fL, P = 0.001). MPV in the diagnosis was significantly higher in the responders than the nonresponders (11.09 and 9.38 fL, P = 0.005). MPV significantly changed after the treatment in the responders (11.09 to 9.32 fL, P = 0.004).
MPV can be used as a predictor of early response to the first line treatment in newly diagnosed adult primary ITP patients.
背景/目的：当需要时，免疫性血小板减少症（ITP）的一线治疗方法是使用皮质类固醇和/或静脉注射免疫球蛋白。平均血小板体积（MPV）是血小板生成和功能的标志物。在这项研究中，我们旨在研究 MPV 与 ITP 患者治疗反应之间的关系，并假设 MPV 可作为反应的预测指标。
纳入了 70 名新诊断的成年原发性 ITP 患者和 70 名健康人。比较了 ITP 和健康人群之间的 MPV、反应者和无反应者之间的诊断和治疗后的 MPV。
与健康人群相比，反应者的 MPV 显著较高，而无反应者的 MPV 显著较低（11.09 和 10.21 fL，P = 0.03；9.38 和 10.21 fL，P = 0.001）。反应者的诊断 MPV 显著高于无反应者（11.09 和 9.38 fL，P = 0.005）。反应者治疗后 MPV 显著变化（11.09 至 9.32 fL，P = 0.004）。
MPV 可作为新诊断的成年原发性 ITP 患者一线治疗早期反应的预测指标。
