急性弛缓性脊髓炎——在澳大利亚儿童中是否未被识别？

Acute flaccid myelitis - has it gone unrecognised in Australian children?

作者信息

Bao Junchao, Thorley Bruce, Elliott Elizabeth J, McIntyre Peter, Britton Phillip N

机构信息

Discipline of Child and Adolescent Health, University of Sydney, NSW; The Children's Hospital at Westmead, NSW.

National Enterovirus Reference Laboratory, the Peter Doherty Institute for Infection and Immunity, Victoria.

出版信息

Commun Dis Intell (2018). 2020 Mar 16;44. doi: 10.33321/cdi.2020.44.22.

DOI:10.33321/cdi.2020.44.22

PMID:32178602

Abstract

We have identified a previously unrecognised cluster of a newly recognised condition - acute flaccid myelitis (AFM) - among acute flaccid paralysis (AFP) cases identified by the Australian Paediatric Active Enhanced Disease Surveillance Network (PAEDS) 2007-2017. In the 12 months before and after detection of enterovirus D68 (EV-D68) from a single AFP case in April 2016, 24 of 97 notified cases of AFP were found to be clinically compatible with AFM; of these 24 cases, ten, clustered in early 2016, met magnetic resonance imaging (MRI) criteria for AFM. Detection of emerging enteroviruses requires collection of respiratory, cerebrospinal fluid and stool specimens, and should be routine practice for all AFP cases.

摘要

在澳大利亚儿科主动强化疾病监测网络（PAEDS）于2007年至2017年确定的急性弛缓性麻痹（AFP）病例中，我们发现了一组此前未被识别的、与一种新确认的病症——急性弛缓性脊髓炎（AFM）相关的病例。在2016年4月从一例AFP病例中检测到肠道病毒D68（EV-D68）之前和之后的12个月里，97例报告的AFP病例中有24例在临床上与AFM相符；在这24例病例中，有10例在2016年初聚集发病，符合AFM的磁共振成像（MRI）标准。检测新出现的肠道病毒需要采集呼吸道、脑脊液和粪便标本，这应该成为所有AFP病例的常规做法。