Africa Health Research Institute, KwaZulu-Natal, South Africa.
School of Nursing and Public Health, University of KwaZulu-Natal, KwaZulu-Natal, South Africa.
Elife. 2020 Mar 17;9:e54012. doi: 10.7554/eLife.54012.
Previously, we demonstrated that coverage of piped water in the seven years preceding a parasitological survey was strongly predictive of infection in a nested cohort of 1976 primary school children (Tanser, 2018). Here, we report on the prospective follow up of infected members of this nested cohort (N = 333) for two successive rounds following treatment. Using a negative binomial regression fitted to egg count data, we found that every percentage point increase in piped water coverage was associated with 4.4% decline in intensity of re-infection (incidence rate ratio = 0.96, 95% CI: 0.93-0.98, p=0.004) among the treated children. We therefore provide further compelling evidence in support of the scaleup of piped water as an effective control strategy against transmission.
此前，我们证明了在寄生虫学调查前的七年中，管道供水的覆盖范围强烈预测了嵌套队列中 1976 名小学生的感染情况（Tanser，2018 年）。在这里，我们报告了对嵌套队列中感染成员的前瞻性随访（N=333），随访时间为两次连续治疗后。使用拟合卵计数数据的负二项式回归，我们发现，每增加一个百分点的管道水覆盖范围，与治疗儿童中再感染强度下降 4.4%相关（发病率比=0.96，95%置信区间：0.93-0.98，p=0.004）。因此，我们提供了进一步的有力证据，支持扩大管道水供应作为一种有效的控制策略，以防止传播。
