Bis Jarosław, Gościńska-Bis Kinga, Gołba Krzysztof S, Gocoł Radosław, Zębalski Marcin, Deja Marek A
Department of Cardiac Surgery, Upper-Silesian Heart Center, Katowice, Poland.
Department of Electrocardiology, Upper-Silesian Heart Center, Katowice, Poland.
J Thorac Cardiovasc Surg. 2021 Sep;162(3):816-824.e3. doi: 10.1016/j.jtcvs.2020.01.082. Epub 2020 Feb 19.
Conduction disturbances necessitating permanent pacemaker (PPM) implantation after cardiac surgery occur in 1% to 5% of patients. Previous studies have reported a low rate of late PPM dependency, but there is lack of evidence that it might be related to implantation timing. In this study, we sought to determine whether PPM implantation timing and specific conduction disturbances as indications for PPM implantation are associated with late pacemaker dependency and recovery of atrioventricular (AV) conduction.
Patients with a PPM implanted after cardiac surgery were followed in an outpatient clinic. Two outcomes were assessed: AV conduction recovery and PPM dependency, defined as the absence of intrinsic rhythm on sensing test in VVI mode at 40 bpm.
Of 15,092 patients operated between September 2008 and March 2019, 185 (1.2%) underwent PPM implantation. One hundred seventy-seven of these patients met the criteria for inclusion into this study. Follow-up data were available in 145 patients (82%). Implantation was performed at ≤6 days after surgery in 58 patients (40%) and at >6 days after surgery in 87 patients (60%). The median time from implantation to last follow-up was 890 days (range, 416-1998 days). At follow-up, 81 (56%) patients were not PPM dependent. Multivariable analysis showed that PPM implantation at ≤6 days after surgery is a predictor of being not PPM dependent (odds ratio [OR], 5.40; 95% confidence interval [CI], 2.43-12.04; P < .001) and of AV conduction recovery (OR, 4.96; 95% CI, 2.26-10.91; P < .001). Sinus node dysfunction as indication for PPM implantation was predictive of being not PPM dependent (OR, 6.59; 95% CI, 1.67-26.06; P = .007).
We recommend implanting a PPM on postoperative day 7 to prevent unnecessary implantations and avoid prolonged hospitalization.
心脏手术后需要植入永久起搏器(PPM)的传导障碍在1%至5%的患者中出现。既往研究报道晚期PPM依赖率较低,但缺乏证据表明其可能与植入时机有关。在本研究中,我们试图确定PPM植入时机以及作为PPM植入指征的特定传导障碍是否与晚期起搏器依赖和房室(AV)传导恢复有关。
对心脏手术后植入PPM的患者进行门诊随访。评估了两个结局:AV传导恢复和PPM依赖,PPM依赖定义为在VVI模式下40次/分时感知测试无固有节律。
在2008年9月至2019年3月接受手术的15092例患者中,185例(1.2%)接受了PPM植入。其中177例患者符合纳入本研究的标准。145例患者(82%)有随访数据。58例患者(40%)在术后≤6天进行植入,87例患者(60%)在术后>6天进行植入。从植入到最后一次随访的中位时间为890天(范围416 - 1998天)。随访时,81例(56%)患者不依赖PPM。多变量分析显示,术后≤6天植入PPM是不依赖PPM的预测因素(比值比[OR],5.40;95%置信区间[CI],2.43 - 12.04;P <.001)以及AV传导恢复的预测因素(OR,4.96;95% CI,2.26 - 10.91;P <.001)。作为PPM植入指征的窦房结功能障碍是不依赖PPM的预测因素(OR,6.59;95% CI,1.67 - 26.06;P =.007)。
我们建议在术后第7天植入PPM,以防止不必要的植入并避免延长住院时间。