Comenius University, Faculty of Medicine and The National Institute of Children's Diseases, Department of Child and Adolescent Psychiatry, Limbová 1, Bratislava 833 40, Slovakia.
Comenius University, Faculty of Medicine and The National Institute of Children's Diseases, Department of Child and Adolescent Psychiatry, Limbová 1, Bratislava 833 40, Slovakia.
Psychiatry Res. 2020 May;287:112911. doi: 10.1016/j.psychres.2020.112911. Epub 2020 Mar 7.
Omega-3 fatty acids (FA) are a promising adjuvant therapy for depressive disorder (DD) in adults. The objective of this single-centre, randomized, double-blind and controlled study was to compare the efficacy of an omega-3 FA fish oil emulsion with a control oil emulsion alongside the standard treatment for depression in children and adolescents suffering from DD or mixed anxiety depressive disorder (MADD) and to analyse serum fatty acid levels and omega-6/omega-3 FA ratio before and after the intervention. 60 children were randomised 1:1 to the intervention (Om3) or active comparator (Om6) groups. Children's Depression Inventory (CDI) ratings were performed at the baseline, every 2 weeks for a 12-week intervention period. Significant reductions in CDI scores were observed after 6 and 12 weeks of intervention in the Om3 group and in the DD subgroup compared to the Om6 and MADD subgroup. Ratio of omega-6/omega-3 decreased in Om3 but not in Om6 from 24.2/1 to 7.6/1 after 6 weeks, EPA, omega-6/omega-3 ratio, but not DHA, correlated with severity symptoms at the baseline. An omega-3 fatty acid rich fish oil emulsion may be an effective adjuvant supplement during the treatment of depressive disorders in children. Trial registration: ISRCTN 81655012.
ω-3 脂肪酸（FA）是成人抑郁障碍（DD）有前途的辅助治疗方法。本单中心、随机、双盲对照研究的目的是比较ω-3 FA 鱼油乳剂与对照油乳剂联合标准治疗对患有 DD 或混合焦虑抑郁障碍（MADD）的儿童和青少年的疗效，并分析干预前后血清脂肪酸水平和 ω-6/ω-3 FA 比值。60 名儿童按 1:1 随机分为干预（Om3）或阳性对照（Om6）组。在基线、12 周干预期间每 2 周进行一次儿童抑郁量表（CDI）评分。干预 6 周和 12 周后，Om3 组和 DD 亚组的 CDI 评分显著降低，与 Om6 和 MADD 亚组相比。与 Om6 组相比，Om3 组的 ω-6/ω-3 比值从 24.2/1 降低至 6 周后的 7.6/1，但 Om6 组的 ω-6/ω-3 比值没有变化。6 周后，EPA、ω-6/ω-3 比值，但不是 DHA，与基线时的严重症状相关。富含 ω-3 脂肪酸的鱼油乳剂可能是儿童抑郁障碍治疗的有效辅助补充剂。试验注册：ISRCTN 81655012。
