Faculty of Medicine, Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia.
Juvenalia, s.r.o, Pediatric Centre, Veľkoblahovská 44A, 929 01 Dunajská Streda, Slovakia.
Nutrients. 2021 Mar 27;13(4):1095. doi: 10.3390/nu13041095.
In the DEPOXIN project, we have found that a high ratio of omega-6/omega-3 fatty acids (FA) is associated with worsening of depressive symptoms in children and adolescents with depressive disorder (DD) and that the 12-week omega-3 FA supplementation modulates DD symptoms. Here we present our results of the secondary outcomes: the levels of thromboxane (TXB), brain-derived neurotrophic factor (BDNF), homocysteine (HCy) and vitamin D. Fifty-eight patients were randomized into two arms. One group received a fish oil emulsion enriched with omega-3 FA, and the other received a sunflower oil emulsion containing omega-6 FA, for 12 weeks. Depressive symptoms were evaluated, using the Child's Depressive Inventory (CDI). The patients with DD had elevated TXB levels and decreased vitamin D levels, as compared to healthy controls. Both CDI and omega-6/omega-3 ratio correlated positively with TXB and negatively with BDNF at baseline. Compared to the omega-6 FA group, the supplementation with omega-3 FA for 12 weeks significantly reduced plasma TXB ( = 0.024) and increased BDNF ( = 0.011) levels. No changes in HCy and vitamin D were observed. Our results demonstrate the possible role of TXB and BDNF in the pathophysiology of DD and the benefits of omega-3 FA supplementation. The study was registered with the ISRCTN registry (ISRCTN81655012).
在 DEPOXIN 项目中，我们发现ω-6/ω-3 脂肪酸（FA）比值升高与伴有抑郁障碍（DD）的儿童和青少年抑郁症状恶化有关，并且 12 周ω-3 FA 补充可调节 DD 症状。在这里，我们介绍了次要结局的结果：血栓素（TXB）、脑源性神经营养因子（BDNF）、同型半胱氨酸（HCy）和维生素 D 的水平。58 名患者随机分为两组。一组接受富含ω-3 FA 的鱼油乳剂，另一组接受富含 ω-6 FA 的葵花籽油乳剂，持续 12 周。使用儿童抑郁量表（CDI）评估抑郁症状。与健康对照组相比，DD 患者的 TXB 水平升高，维生素 D 水平降低。CDI 和 ω-6/ω-3 比值与 TXB 和 BDNF 在基线时均呈正相关。与 ω-6 FA 组相比，12 周补充 ω-3 FA 可显著降低血浆 TXB（=0.024）和增加 BDNF（=0.011）水平。HCy 和维生素 D 无变化。我们的研究结果表明 TXB 和 BDNF 可能在 DD 的病理生理学中起作用，以及 ω-3 FA 补充的益处。该研究在 ISRCTN 注册处（ISRCTN81655012）进行了注册。
