Bolon B, St Omer V E
Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia 65211.
Toxicol Lett. 1988 Dec;44(3):263-72. doi: 10.1016/0378-4274(88)90165-8.
Mice were gavage-fed on day 13 of pregnancy with 0 (groups N, 15, 25) or 25 (group P) mg/kg of secalonic acid D (SAD) and again while nursing their offspring on postgestational days 1-10 with 0 (N,P), 15(15) or 25(25) mg/kg/day. SAD residues were present in the stomach of pups nursed by SAD-treated dams. Postnatal exposure to SAD decreased (P less than 0.05) body weight gains of offspring. Treatment decreased the developmental levels of norepinephrine and dopamine in the prosencephalon (forebrain) and cerebellum-pons of the offspring on postnatal days (PND) 7 and 7-16, respectively. On PND 7-16 serotonin and 5-hydroxyindoleacetic acid levels decreased in the prosencephalon and cerebellum-pons of offspring exposed prenatally (P) or postnatally (15,25) to SAD.
在怀孕第13天，给小鼠灌胃0毫克/千克（N组、15组、25组）或25毫克/千克（P组）的黑麦角环肽D（SAD），在产后第1 - 10天哺乳后代时，再次分别给予0毫克/千克/天（N组、P组）、15毫克/千克/天（15组）或25毫克/千克/天（25组）。由经SAD处理的母鼠哺乳的幼崽胃中存在SAD残留。产后接触SAD会降低（P < 0.05）后代的体重增加。处理分别降低了产后第7天和第7 - 16天后代前脑（端脑）和小脑 - 脑桥中去甲肾上腺素和多巴胺的发育水平。在产后第7 - 16天，产前（P组）或产后（15组、25组）接触SAD的后代前脑和小脑 - 脑桥中血清素和5 - 羟基吲哚乙酸水平降低。
