Toll样受体9基因多态性可能导致EB病毒感染鼻咽癌的种族差异。
TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma.
作者信息
Roy Chattopadhyay Nabanita, Chatterjee Koustav, Tiwari Nikhil, Chakrabarti Sudipta, Sahu Sushil Kumar, Deb Roy Sankar, Ghosh Arijit, Reddy R Rajendra, Das Piyanki, Mal Sudipa, Karnar Basab Bijay, Das Ashok Kumar, Tsering Sam, Riba Komri, Puii Zoreng, Zomawia Eric, Singh Y Indibar, Suryawanshi Amol Ratnakar, Kumar Abhishek, Ganguly Dipyaman, Goswami Chandan, Choudhuri Tathagata
机构信息
Department of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India.
School of Biological Science, National Institute of Science Education and Research, Padnpur, Odisha 752050, India.
出版信息
iScience. 2020 Mar 27;23(3):100937. doi: 10.1016/j.isci.2020.100937. Epub 2020 Feb 28.
Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of <0.0001 at a significance level of 0.05. These might play an important role for the lack of function of TLR9 and thus for the higher occurrence of EBV-mediated NPC in such ethnic groups.
鼻咽癌（NPC）在世界大部分地区是一种罕见的恶性肿瘤，但在一些种族群体中呈地方流行。NPC与爱泼斯坦-巴尔病毒（EBV）的关联已得到确凿证实；然而，其机制仍不清楚。TLR9因其在病毒病原体识别和先天免疫激活中的关键作用而闻名。在此，我们报告了一组从来自印度东北部具有上述种族的EBV感染NPC样本中收集的TLR9蛋白TIR-2结构域中的TLR9多态性。这些样本中突变的发生率显著较高，因为我们在0.05的显著性水平下发现p值<0.0001。这些突变可能对TLR9功能缺失起重要作用，进而导致此类种族群体中EBV介导的NPC发生率较高。
Zotero 插件