Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network EpiCARE, Kuopio, Finland.
Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network EpiCARE, Kuopio, Finland; Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Epilepsy Behav. 2020 May;106:107015. doi: 10.1016/j.yebeh.2020.107015. Epub 2020 Mar 14.
Juvenile myoclonic epilepsy (JME) is a common genetic generalized epilepsy syndrome. Adult patients with JME have shown a neuropsychological profile suggestive of subtle frontal dysfunction, but studies of cognitive functioning in the early phases of JME are rare. We analyzed the cognitive performance data of 18 patients who had undergone a neuropsychological assessment either at the time of JME diagnosis and before the initiation of an antiepileptic drug (AED) treatment (11 patients) or during the first 6 years after JME diagnosis (seven patients).
The cognitive performance of the18 patients with JME (mean age: 18.1, range: 15-33 years) and 18 healthy controls (mean age: 18.7, range: 15-25 years) was compared in a retrospective study. The assessed cognitive domains were visuomotor speed, attention, executive function, and verbal memory.
The patients with JME and the healthy controls did not differ in any of the assessed cognitive domains. The clinical variables did not correlate to cognitive performance. Furthermore, cognitive performance did not differ between the patients evaluated at the time of diagnosis and before the initiation of AEDs and the patients evaluated during the first 6 years after diagnosis and with an AED treatment.
The cognitive performance of patients with new-onset JME was similar to healthy controls. We could not detect the frontal dysfunction that has been suggested to be associated with JME. Patients were in adolescence or early adulthood with a short duration of epilepsy, which may have contributed to the discovery of no cognitive impairments.
青少年肌阵挛癫痫（JME）是一种常见的遗传性全面性癫痫综合征。成年 JME 患者表现出轻微额叶功能障碍的神经心理学特征，但 JME 早期认知功能的研究较为罕见。我们分析了 18 例患者的认知表现数据，这些患者在 JME 诊断时和开始抗癫痫药物（AED）治疗之前（11 例）或在 JME 诊断后 6 年内（7 例）接受了神经心理学评估。
在回顾性研究中，比较了 18 例 JME 患者（平均年龄：18.1 岁，范围：15-33 岁）和 18 名健康对照者（平均年龄：18.7 岁，范围：15-25 岁）的认知表现。评估的认知领域包括视动速度、注意力、执行功能和言语记忆。
JME 患者和健康对照组在任何评估的认知领域均无差异。临床变量与认知表现无关。此外，在诊断时和开始 AED 治疗前评估的患者与在诊断后 6 年内和使用 AED 治疗的患者之间，认知表现也没有差异。
新发 JME 患者的认知表现与健康对照组相似。我们未发现与 JME 相关的额叶功能障碍。患者处于青春期或成年早期，癫痫持续时间较短，这可能导致未发现认知障碍。
