21-羟基孕甾-4-烯-3,20-二酮（脱氧皮质酮）衍生物化合物的结构分析。第一部分：合成与圆二色性鉴定。

Structural analysis of 21-hydroxypregn-4-ene-3,20-dione (deoxycorticosterone) derivative compounds. Part I: Synthesis and circular dichroism identification.

作者信息

Kouadio L, Bernard P, Sabot J F, Petit-Ramel M M, Barbier C M, Pinatel H J

机构信息

Laboratoire de Chimie Analytique II, Hopital de l'Antiquaille, Universite Claude Bernard Lyon, France.

出版信息

Steroids. 1988 Mar-Apr;51(3-4):349-61. doi: 10.1016/0039-128x(88)90024-4.

DOI:10.1016/0039-128x(88)90024-4

PMID:3217959

Abstract

Deoxycorticosterone (DOC) derivative compounds (DOC, DOC 21-acetate, and 7-mercaptopropionic DOC) have been prepared and purified by high pressure liquid chromatography. Synthesis products have been identified, and three chromophores have been displayed by their n----II and II----II dichroic transitions. A normal half-chair conformation is favored in ring A.

摘要

已制备出脱氧皮质酮（DOC）衍生物化合物（DOC、21-乙酸脱氧皮质酮和7-巯基丙酸脱氧皮质酮），并通过高压液相色谱法进行了纯化。已鉴定出合成产物，并且通过其n→π和π→π二向色性跃迁显示出三种发色团。A环中倾向于正常的半椅构象。