Emergency Department, Ng Teng Fong General Hospital, Singapore.
Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, St Thomas' Hospital; Faculty of Life Sciences and Medicine, King's College London, London, UK.
Singapore Med J. 2022 Oct;63(10):572-576. doi: 10.11622/smedj.2020024. Epub 2020 Mar 17.
Misuse of prescription medicines and the harms associated with such use are growing threats across the world. There is currently, however, limited data on the extent of prescription medicine misuse in Singapore and whether this is a current threat in the country.
An online survey, limited to 1,000 individuals (aged 21 years and over) who were residents in Singapore, was administered through a survey panel company in September 2015. The survey collected information on participant demographics, and their awareness, self-reported lifetime and past-year misuse of commonly available prescription medicines in Singapore as well as the use of a range of recreational drugs and novel psychoactive substances (NPS).
Lifetime (6.7%) and past-year (4.8%) misuse of any prescription medicine was comparable to lifetime (6.0%) and past-year (3.0%) use of any recreational drugs/NPS. The top five prescription medicines for lifetime misuse were: diazepam (2.7%); codeine (2.3%); dhasedyl (promethazine, codeine and ephedrine; 1.6%); panadeine (paracetamol and codeine; 1.5%); and methylphenidate (1.2%). The top five drugs for past-year misuse were: diazepam (1.6%); codeine (0.9%); panadeine (0.7%); alprazolam (0.6%); baclofen (0.6%); and gabapentin (0.6%).
Misuse of prescription medicine in Singapore was common, with prevalence comparable to the use of recreational drugs/NPS. A common source for misused drugs was physicians. Further studies are required to determine whether this is more widespread in Singapore and establish the different forms of drug diversion, so that appropriate prevention strategies can be implemented.
在全球范围内,处方药物的滥用及其相关危害日益严重。然而,目前新加坡关于处方药物滥用程度的数据有限,也不确定这是否是新加坡当前面临的威胁。
2015 年 9 月,通过调查小组公司对新加坡的 1000 名(年龄在 21 岁及以上)居民进行了一项在线调查,仅限于新加坡居民。该调查收集了参与者人口统计学信息,以及他们对在新加坡常见的处方药物的认知、自我报告的终生和过去一年的滥用情况,以及一系列娱乐性药物和新型精神活性物质(NPS)的使用情况。
终生(6.7%)和过去一年(4.8%)滥用任何处方药物与终生(6.0%)和过去一年(3.0%)滥用任何娱乐性药物/NPS 相似。终生滥用最多的五种处方药物为:地西泮(2.7%);可待因(2.3%);海洛因(右美沙芬、可待因和麻黄碱;1.6%);扑热息痛和可待因(1.5%);哌甲酯(1.2%)。过去一年滥用最多的五种药物为:地西泮(1.6%);可待因(0.9%);扑热息痛和可待因(0.7%);阿普唑仑(0.6%);巴氯芬(0.6%);加巴喷丁(0.6%)。
新加坡处方药物滥用很常见,其流行程度与娱乐性药物/NPS 相当。医生是误用药物的常见来源。需要进一步研究以确定这种情况在新加坡是否更为普遍,并确定不同形式的药物转移,以便实施适当的预防策略。