非侵入性超声刺激伏隔核可诱导行为回避。
Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance.
机构信息
Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
出版信息
Sci China Life Sci. 2020 Sep;63(9):1328-1336. doi: 10.1007/s11427-019-1616-6. Epub 2020 Mar 13.
Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens (NAc) in freely moving mice. Our results show that an acute ultrasound stimulation on the NAc, rather than the visual cortex or auditory cortex, led to a pronounced avoidance behavior, while repeated NAc ultrasound stimulation resulted in an obvious conditioned place aversion with changes in synaptic protein (GluA1/2 subunit) expression. Notably, NAc ultrasound stimulation suppressed the morphine-induced conditioned place preference. The results provide evidence that NAc ultrasound stimulation can be applied as a potential noninvasive therapeutic option in treating psychiatric disorders.
超声刺激是一种新兴的治疗神经精神疾病的非侵入性方法。本研究探讨了在自由活动的小鼠中，对伏隔核（NAc）进行超声刺激所导致的行为改变。我们的结果表明，急性超声刺激 NAc 而非视觉皮层或听觉皮层，会导致明显的回避行为，而重复 NAc 超声刺激会导致突触蛋白（GluA1/2 亚基）表达的明显条件性位置厌恶。值得注意的是，NAc 超声刺激抑制了吗啡引起的条件性位置偏好。这些结果为 NAc 超声刺激可作为治疗精神疾病的一种潜在非侵入性治疗选择提供了证据。
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