Xu Ying, Lin Yingjie, Yu Ming, Zhou Kuikui
School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China.
Front Behav Neurosci. 2024 Aug 9;18:1420028. doi: 10.3389/fnbeh.2024.1420028. eCollection 2024.
The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been implicated in a wide range of behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that the function of the NAc in reward and aversion processing is multifaceted. Prolonged stress or drug use induces maladaptive neuronal function in the NAc circuitry, which results in pathological conditions. This review aims to provide comprehensive and up-to-date insights on the role of the NAc in motivated behavior regulation and highlights areas that demand further in-depth analysis. It synthesizes the latest findings on how distinct NAc neuronal populations and pathways contribute to the processing of opposite valences. The review examines how a range of neuromodulators, especially monoamines, influence the NAc's control over various motivational states. Furthermore, it delves into the complex underlying mechanisms of psychiatric disorders such as addiction and depression and evaluates prospective interventions to restore NAc functionality.
伏隔核（NAc）是大脑奖赏回路的核心组成部分，与多种行为和情绪状态有关。主要来自近期啮齿动物研究的新证据表明，NAc在奖赏和厌恶处理中的功能是多方面的。长期应激或药物使用会在NAc回路中诱导适应性不良的神经元功能，从而导致病理状况。本综述旨在提供关于NAc在动机行为调节中的作用的全面和最新见解，并突出需要进一步深入分析的领域。它综合了关于不同NAc神经元群体和通路如何促成相反效价处理的最新发现。该综述研究了一系列神经调质，特别是单胺，如何影响NAc对各种动机状态的控制。此外，它深入探讨了成瘾和抑郁症等精神疾病的复杂潜在机制，并评估了恢复NAc功能的前瞻性干预措施。
