Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Jiulong, Hong Kong SAR, China.
Neurosci Bull. 2021 May;37(5):735-745. doi: 10.1007/s12264-021-00667-y. Epub 2021 Apr 19.
Stem cell transplantation holds a promising future for central nervous system repair. Current challenges, however, include spatially and temporally defined cell differentiation and maturation, plus the integration of transplanted neural cells into host circuits. Here we discuss the potential advantages of neuromodulation-based stem cell therapy, which can improve the viability and proliferation of stem cells, guide migration to the repair site, orchestrate the differentiation process, and promote the integration of neural circuitry for functional rehabilitation. All these advantages of neuromodulation make it one potentially valuable tool for further improving the efficiency of stem cell transplantation.
干细胞移植为中枢神经系统修复带来了广阔的前景。然而,目前面临的挑战包括空间和时间限定的细胞分化和成熟,以及移植的神经细胞与宿主回路的整合。在此,我们讨论了基于神经调节的干细胞治疗的潜在优势,它可以提高干细胞的活力和增殖,引导其迁移到修复部位,协调分化过程,并促进神经回路的整合,从而实现功能康复。神经调节的所有这些优势使其成为进一步提高干细胞移植效率的一种有潜力的工具。