糖尿病大动物模型。

Large Animal Models of Diabetes.

机构信息

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Faculty of Medicine of the TU Dresden, Dresden, Germany.

出版信息

Methods Mol Biol. 2020;2128:115-134. doi: 10.1007/978-1-0716-0385-7_9.

DOI:10.1007/978-1-0716-0385-7_9

PMID:32180190

Abstract

Safe and reliable large animal diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents but is often critiqued in higher animals due to reduced efficacy, relevant side effects, and inadequate mortality rate. In this chapter, we aim to describe both pharmacological and surgical approaches for reproducible and safe diabetes models in minipigs and primates. In addition, genetically modified pig models for diabetes research are described.

摘要

安全可靠的大动物糖尿病模型是高级临床前糖尿病研究的关键前提。化学诱导是啮齿动物糖尿病的标准模型，但在较高等动物中，由于疗效降低、相关副作用和死亡率不足，常受到批评。在本章中，我们旨在描述用于小型猪和灵长类动物的可重复和安全的糖尿病模型的药理学和手术方法。此外，还描述了用于糖尿病研究的基因修饰猪模型。