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血管内生长侵犯性胸腺瘤累及大静脉和右心房:1 例报告。

Invasive thymoma with intravascular growth into the great veins and right atrium: A case report.

机构信息

Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Tianjin Medical University General Hospital, Tianjin, China.

出版信息

Thorac Cancer. 2020 May;11(5):1326-1329. doi: 10.1111/1759-7714.13242. Epub 2020 Mar 17.

DOI:10.1111/1759-7714.13242
PMID:32180340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7180703/
Abstract

Here, we present a case of invasive thymoma with intraluminal growth into the left and right brachiocephalic veins, superior vena cava and the right atrium. Resection of the mass, double partial upper lobe lobectomy and superior vena cava, and left and right brachiocephalic vein replacement were performed. Pathological diagnosis indicated a mixed histological pattern indicative of type B1 and type B2 thymoma, predominantly type B2 thymoma. The patient was well and without local recurrence or distal metastasis after 50 months of follow-up.

摘要

在这里,我们报告一例侵袭性胸腺瘤,肿瘤向左侧和右侧头臂静脉、上腔静脉和右心房腔内生长。我们进行了肿块切除术、双肺上叶部分切除术和上腔静脉及左右头臂静脉置换术。病理诊断提示为 B1 型和 B2 型混合组织学模式的胸腺瘤,主要为 B2 型胸腺瘤。患者在 50 个月的随访中情况良好,无局部复发或远处转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0861/7180703/f2f6c7f88b5e/TCA-11-1326-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0861/7180703/ed4c57902119/TCA-11-1326-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0861/7180703/0d378d78ac0f/TCA-11-1326-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0861/7180703/f2f6c7f88b5e/TCA-11-1326-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0861/7180703/ed4c57902119/TCA-11-1326-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0861/7180703/0d378d78ac0f/TCA-11-1326-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0861/7180703/f2f6c7f88b5e/TCA-11-1326-g003.jpg

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1
Invasive thymoma with intravascular growth into the great veins and right atrium: A case report.血管内生长侵犯性胸腺瘤累及大静脉和右心房:1 例报告。
Thorac Cancer. 2020 May;11(5):1326-1329. doi: 10.1111/1759-7714.13242. Epub 2020 Mar 17.
2
[Mediastinal malignant tumor resection and superior vena cava revascularization. Resection of invasive thymoma with growth into the superior vena cava and right atrium using cardiopulmonary bypass].[纵隔恶性肿瘤切除术及上腔静脉血管重建。采用体外循环切除侵犯上腔静脉及右心房的侵袭性胸腺瘤]
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Invasive thymoma with intracaval growth extending and directly invading the right atrium.侵袭性胸腺瘤伴腔内生长,肿瘤延伸并直接侵犯右心房。
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Pathol Int. 2013 Jan;63(1):56-62. doi: 10.1111/pin.12023. Epub 2012 Dec 25.
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Invasive Thymoma Protruding into the Superior Vena Cava through the Thymic Vein.侵袭性胸腺瘤经胸腺静脉突入上腔静脉。
Ann Thorac Cardiovasc Surg. 2016;22(2):122-4. doi: 10.5761/atcs.cr.15-00149. Epub 2015 Aug 21.
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[Surgical treatment in a case of malignant thymoma extending from the left brachiocephalic vein to the superior vena cava and the right atrium].[1例恶性胸腺瘤自左头臂静脉延伸至 superior vena cava 和右心房的外科治疗] (注:superior vena cava 一般译为上腔静脉,但这里原文未翻译为中文,直接保留了英文)
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[Intravascular invasion of a thymoma from the thymic vein to the right atrium--a case report].[胸腺瘤经胸腺静脉至右心房的血管内侵犯——一例报告]
Nihon Kyobu Geka Gakkai Zasshi. 1996 Jul;44(7):998-1002.
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Radical operation for invasive thymoma with intracaval, intracardiac, and lung invasion.侵袭性胸腺瘤侵犯腔静脉、心脏及肺的根治性手术。
J Card Surg. 2007 Jul-Aug;22(4):330-2. doi: 10.1111/j.1540-8191.2007.00417.x.

引用本文的文献

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Thymoma with Intravascular Tumor Thrombus in the Left Brachiocephalic Vein: A Case Report.左头臂静脉内伴血管内肿瘤血栓的胸腺瘤:一例报告
Surg Case Rep. 2025;11(1). doi: 10.70352/scrj.cr.25-0118. Epub 2025 Jul 1.
2
A rare journey of a thymoma: A case report.胸腺瘤的罕见病程:一例报告
Int J Surg Case Rep. 2025 Feb;127:110891. doi: 10.1016/j.ijscr.2025.110891. Epub 2025 Jan 13.
3
The 100 most cited papers on thymoma: a bibliometric analysis.胸腺肿瘤 100 篇被引频次最高的论文:文献计量分析。

本文引用的文献

1
Alteration in gene expression profiles of thymoma: Genetic differences and potential novel targets.胸腺瘤基因表达谱的改变:遗传差异和潜在的新靶点。
Thorac Cancer. 2019 May;10(5):1129-1135. doi: 10.1111/1759-7714.13053. Epub 2019 Apr 1.
2
Genetic characterization of thymoma.胸腺瘤的遗传学特征。
Sci Rep. 2019 Feb 20;9(1):2369. doi: 10.1038/s41598-019-38878-z.
3
[Thymoma with immunodeficiency/Good syndrome associated with myasthenia gravis].[胸腺瘤伴免疫缺陷/古德综合征合并重症肌无力]
J Cardiothorac Surg. 2023 Apr 7;18(1):107. doi: 10.1186/s13019-023-02201-9.
4
Case report: Complete resection of invasive thymoma invading the superior vena cava and right atrium under cardiopulmonary bypass support.病例报告:在体外循环支持下完整切除侵犯上腔静脉和右心房的侵袭性胸腺瘤。
Front Oncol. 2022 Oct 20;12:1026524. doi: 10.3389/fonc.2022.1026524. eCollection 2022.
5
Thymomas With Intravascular and Intracardiac Growth.伴有血管内和心内生长的胸腺瘤
Front Oncol. 2022 Jun 24;12:881553. doi: 10.3389/fonc.2022.881553. eCollection 2022.
6
Surgical feasibility and long-term outcome of superior vena cava replacement for advanced thymoma in patients undergoing preoperative chemotherapy or chemoradiotherapy.术前化疗或放化疗后进展性胸腺瘤患者行上腔静脉置换术的手术可行性及长期疗效。
Thorac Cancer. 2021 Apr;12(7):1074-1083. doi: 10.1111/1759-7714.13872. Epub 2021 Feb 10.
Rinsho Shinkeigaku. 2017 May 27;57(5):208-213. doi: 10.5692/clinicalneurol.cn-000984. Epub 2017 Apr 27.
4
Multiorgan autoimmune manifestations associated with thymoma.与胸腺瘤相关的多器官自身免疫表现。
J Thorac Oncol. 2015 Feb;10(2):e5-7. doi: 10.1097/JTO.0000000000000324.
5
Superior vena cava obstruction by tumour thrombus in invasive thymoma: diagnosis and surgical management.侵袭性胸腺瘤中肿瘤血栓导致上腔静脉梗阻:诊断与外科治疗
Heart Lung Circ. 2007 Dec;16(6):462-4. doi: 10.1016/j.hlc.2006.08.010. Epub 2007 Apr 10.
6
Extended thymectomy for myasthenia gravis patients: a 20-year review.重症肌无力患者的扩大胸腺切除术:20年回顾
Ann Thorac Surg. 1996 Sep;62(3):853-9. doi: 10.1016/s0003-4975(96)00376-1.
7
Malignant thymoma presenting as intracardiac tumor and superior vena caval obstruction.表现为心内肿瘤及上腔静脉梗阻的恶性胸腺瘤。
Ann Thorac Surg. 1990 Dec;50(6):989-91. doi: 10.1016/0003-4975(90)91143-y.