Abdelnabi Mahmoud, Almaghraby Abdallah, Saleh Yehia
Cardiology and Angiology Unit, Department of Clinical and Experimental Internal Medicine, Medical Research Institute, University of Alexandria, Egypt.
Department of Cardiology, Faculty of Medicine, University of Alexandria, Egypt.
Eur Cardiol. 2020 Feb 26;15:1-2. doi: 10.15420/ecr.2019.1.3. eCollection 2020 Feb.
Although there are abundant data highlighting the safety and efficacy of direct oral anticoagulants, to date, recent guidelines have limited their use to stroke prevention in patients with non-valvular AF, as well as in the prevention and treatment of venous thromboembolism and pulmonary embolism. Encouraging data about the off-label use of direct oral anticoagulants have been shown in several other indications, such as intracardiac thrombi, left ventricular thrombi and left atrial appendage, but a large sector of patients are still not addressed, such as valvular and prosthetic patients.
尽管有大量数据凸显了直接口服抗凝剂的安全性和有效性，但迄今为止，近期的指南将其使用局限于非瓣膜性房颤患者的卒中预防，以及静脉血栓栓塞和肺栓塞的预防与治疗。在心脏内血栓、左心室血栓和左心耳等其他一些适应症中，已显示出关于直接口服抗凝剂超说明书使用的鼓舞人心的数据，但仍有很大一部分患者未得到关注，例如瓣膜病患者和人工瓣膜患者。
