Makar Gabriel S, Makar Michael, Ghobrial Joanna, Bush Kathryn, Gruner Ryan Allen, Holdbrook Thomas
Cooper Medical School of Rowan University, 401 Broadway Ave, Camden, NJ 08103, USA.
Robert Wood Johnson University Hospital, 1 Robert Wood Johnson Pl, New Brunswick, NJ 08901, USA.
Case Rep Oncol Med. 2020 Feb 28;2020:1989452. doi: 10.1155/2020/1989452. eCollection 2020.
Primary breast neoplasms are rare in adolescent females, most of which are benign. Phyllodes tumors constitute a remarkably small subset of breast neoplasms (0.3-0.9%) with malignant phyllodes tumors being even more uncommon. Malignant phyllodes tumors tend to progress rapidly though only 1.5% metastasize. They are also associated with a higher rate of recurrence than their benign counterparts, underlying the importance of adequate surgical margins. It is therefore imperative to be able to identify these tumors early allowing for prompt resection and close follow-up. Here, we present the rare case of a 17-year-old female presenting with a rapidly enlarging breast mass, which was ultimately found to be a malignant phyllodes tumor. We further performed a review of the literature to highlight only 22 other cases reported in adolescent females.
原发性乳腺肿瘤在青春期女性中较为罕见，其中大多数为良性。叶状肿瘤在乳腺肿瘤中所占比例极小（0.3 - 0.9%），恶性叶状肿瘤更为罕见。恶性叶状肿瘤往往进展迅速，不过仅有1.5%会发生转移。与良性叶状肿瘤相比，其复发率也更高，这凸显了足够手术切缘的重要性。因此，能够早期识别这些肿瘤以便及时切除并密切随访至关重要。在此，我们报告一例罕见病例，一名17岁女性出现乳腺肿块迅速增大，最终被诊断为恶性叶状肿瘤。我们还进一步查阅了文献，发现青春期女性中仅另有22例相关病例报道。
