Bolem Nagarjun, Nga Vincent Diong Weng, Chou Ning, Yeo Tseng Tsai, Lin Jeremy, Sharma Vijay K
Division of Neurosurgery, University Surgical Cluster, National University Hospital, Singapore.
Department of Pediatric Medicine, Division of Pediatric Neurology, National University Hospital, Singapore.
Asian J Neurosurg. 2020 Feb 25;15(1):194-197. doi: 10.4103/ajns.AJNS_218_19. eCollection 2020 Jan-Mar.
Moyamoya disease (MMD) is an incompletely understood malady that affects many age groups, primarily in a bimodal age distribution. We present a patient with the association of type 1 diabetes mellitus (type 1 DM) and MMD followed by a review of the existing literature. We found five papers that describe this association, in the form of one case report, one case series, and three retrospective reviews. Despite a poor understanding of the underlying pathophysiology, a clear association between autoimmune conditions and MMD appears to exist. Clinicians who manage such patients ought to be vigilant and have a high index of suspicion when young patients with type 1 DM present with new onset of neurological symptoms.
烟雾病（MMD）是一种尚未被完全理解的疾病，影响多个年龄组，主要呈双峰年龄分布。我们报告一例1型糖尿病（1型DM）与烟雾病相关的病例，并对现有文献进行综述。我们发现五篇论文描述了这种关联，形式包括一篇病例报告、一篇病例系列和三篇回顾性综述。尽管对潜在的病理生理学了解不足，但自身免疫性疾病与烟雾病之间似乎存在明确关联。对于这类患者进行管理的临床医生，当1型DM的年轻患者出现新发神经症状时，应保持警惕并高度怀疑。
