Bruno Zanotti, Angelo Nataloni, Riccardo Spaggiari, Nicola Zingaretti, Stefano Pizzolitto, Camillo Parodi Pier, Federico Nicolosi, Carlotta Morselli
Department of Neuroscience, "C. Poma" Hospital, Mantova, Italy.
Department of Clinic, FinCeramica Faenza, RA, Italy.
Asian J Neurosurg. 2020 Feb 25;15(1):198-203. doi: 10.4103/ajns.AJNS_208_19. eCollection 2020 Jan-Mar.
Custom-made cranial implants facilitate the surgical reconstruction of destructive pathologies of the skull or extensive demolitive skull surgery. Customized cranioplasty allows for an immediate restoration of the functional integrity of the cranial defect (), with excellent functional and esthetic outcome and a quick, safe, and simple procedure. In this context, bioceramics like hydroxyapatite (HA) claim high biocompatibility and bone-binding capability. The osteoconductive properties of the HA have been reported in animal models and humans. The purpose of this study is to demonstrate with radiological and histological examination and how HA prosthesis may integrate after their implantation showing data related to five patients that needed primary HA cranial reconstruction with secondary removal after few years. The histological examination showed neo-formed lamellar/trabecular bone tissue fragments accompanied by the amorphous reticular tissue (HA prosthesis) revealing diffuse ossification sites in all included cases.
定制的颅骨植入物有助于对头骨的破坏性病变进行手术重建或进行广泛的颅骨切除手术。定制颅骨成形术可立即恢复颅骨缺损的功能完整性，具有出色的功能和美学效果，且手术快速、安全、简单。在这种情况下，像羟基磷灰石（HA）这样的生物陶瓷具有高度的生物相容性和骨结合能力。HA的骨传导特性已在动物模型和人类中得到报道。本研究的目的是通过放射学和组织学检查来证明HA假体植入后如何整合，并展示与五名需要进行初次HA颅骨重建并在数年后进行二次取出的患者相关的数据。组织学检查显示，在所有纳入的病例中，均有新形成的板层/小梁骨组织碎片伴有无定形网状组织（HA假体），揭示了弥漫性骨化部位。
