Small Gary R, Erthal Fernanda, Alenazy Ali, Yam Yeung, Edwards Michael, Crean Andrew, Beanlands Rob S, Ruddy Terrence D, Chow Benjamin J W
University of Ottawa Heart Institute, Division of Cardiology, Canada.
University of Ottawa, Department of Radiology, Canada.
Int J Cardiol Heart Vasc. 2020 Mar 5;27:100494. doi: 10.1016/j.ijcha.2020.100494. eCollection 2020 Apr.
The impact of anatomical versus functional testing in patients with prior coronary artery bypass surgery (CABG) is poorly defined. We therefore sought to determine the rates of downstream investigations and the attendant healthcare costs in CABG patients undergoing CCTA versus SPECT.
2754 consecutive CABG patients were imaged by SPECT (2163) or CCTA (591). 425 patients (15.4%) underwent downstream testing which was more common in those imaged with CCTA versus SPECT (23.18% vs 13.31% respectively, p < 0.01). When a propensity score adjustment was made for differences in baseline characteristics, the findings in downstream testing persisted (p < 0.01). When patients who subsequently underwent repeat revascularization (arguably the highest risk patients) were removed from the analysis, downstream testing remained more frequent in CCTA (12.7%) versus SPECT imaged patients (8.8%) (p = 0.01). Costs of downstream tests per patient were two-fold greater in the CCTA group in comparison to the SPECT group ($366.79 ± 29.59 vs $167.35 ± 10.12 respectively, p < 0.01). Conversely, total costs which included the index costs were less in the CCTA group, $764.66 ± 29.59 versus $1396.73 ± 1012 for the SPECT cohort, p < 0.0001).
Index imaging with SPECT versus CCTA in CABG patients was associated with fewer downstream tests, less ICA, less repeat revascularization but greater expense. Cost however is only part of the decision making process that determines an optimal index test. Until CCTA demonstrates improved risk stratification over SPECT in CABG patients it is likely SPECT will remain the preferred first imaging test.
对于曾接受冠状动脉旁路移植术(CABG)的患者,解剖学检查与功能检查的影响尚不明确。因此,我们试图确定接受心脏CT血管造影(CCTA)与单光子发射计算机断层扫描(SPECT)的CABG患者进行下游检查的比例及相应的医疗费用。
2754例连续的CABG患者接受了SPECT(2163例)或CCTA(591例)检查。425例患者(15.4%)接受了下游检查,在接受CCTA检查的患者中比接受SPECT检查的患者更常见(分别为23.18%和13.31%,p<0.01)。当对基线特征差异进行倾向评分调整时,下游检查的结果仍然存在(p<0.01)。当将随后接受再次血运重建的患者(可以说是风险最高的患者)从分析中排除后,CCTA检查的患者(12.7%)下游检查仍然比SPECT检查的患者(8.8%)更频繁(p=0.01)。CCTA组每位患者的下游检查费用是SPECT组的两倍(分别为366.79美元±29.59美元和167.35美元±10.12美元,p<0.01)。相反,包括首次检查费用在内的总费用在CCTA组较低,CCTA组为764.66美元±29.59美元,SPECT组为1396.73美元±1012美元,p<0.0001)。
CABG患者中,与CCTA相比,采用SPECT进行首次成像检查与更少的下游检查、更少的侵入性冠状动脉造影(ICA)、更少的再次血运重建相关,但费用更高。然而,费用只是决定最佳首次检查的决策过程的一部分。在CABG患者中,直到CCTA显示出比SPECT更好的风险分层之前,SPECT可能仍然是首选的首次成像检查。