Department of Otorhinolaryngology-Head and Neck Surgery, 155983University Hospital Münster, Germany.
Institute of Immunology, 155983University Hospital Münster, Germany.
Ear Nose Throat J. 2021 Sep;100(5_suppl):822S-827S. doi: 10.1177/0145561320910682. Epub 2020 Mar 17.
Tonsillectomy (TE) and tonsillotomy (TO) due to recurrent episodes of acute tonsillitis (RAT) belong to the most frequent surgical procedures. However, an adequate objective marker predicting the outcome of TE/TO preoperatively is missing.
Patients with RAT who underwent TE/TO (n = 31) were included in this pilot study. A panel of cytokines and chemokines in serum and saliva were determined preoperatively. Health-related quality of life was assessed pre- and postoperatively by the Tonsillectomy Outcome Inventory-14.
Health-related quality of life improved significantly after surgery. Increased serum levels of interleukin-8 (IL-8) and interferon gamma (IFN-γ) are associated with a less successful outcome. No correlation between the number of acute tonsillitis episodes and the health-related quality of life after TE or TO could be observed.
Tonsillectomy and TO improve health-related quality of life independently from the number of past acute tonsillitis episodes. Interleukin-8 and IFN-γ in serum may serve as promising markers, predicting the benefit of TE or TO for patients preoperatively.
由于复发性急性扁桃体炎（RAT）而进行的扁桃体切除术（TE）和扁桃体切开术（TO）属于最常见的手术之一。然而，目前缺乏一种术前能够充分预测 TE/TO 治疗效果的客观指标。
本研究纳入了 31 例 RAT 患者，他们均接受了 TE/TO。在术前检测了血清和唾液中的细胞因子和趋化因子。通过扁桃体切除术结果问卷-14 评估了术前和术后的健康相关生活质量。
手术后健康相关生活质量显著改善。血清中白细胞介素-8（IL-8）和干扰素γ（IFN-γ）水平升高与治疗效果较差相关。TE 或 TO 后，急性扁桃体炎发作次数与健康相关生活质量之间无相关性。
TE 和 TO 可改善健康相关生活质量，与过去急性扁桃体炎发作次数无关。血清中的白细胞介素-8 和干扰素γ可能是有前途的预测指标，可术前预测 TE 或 TO 对患者的获益。
