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扁桃体切除术:事实与虚构

Tonsillotomy: facts and fiction.

作者信息

Windfuhr J P, Savva K, Dahm J D, Werner J A

机构信息

Department of Otorhinolaryngology, Plastic Head and Neck Surgery, Kliniken Maria Hilf Mönchengladbach, Sandradstr. 43, 41061, Mönchengladbach, Germany.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany.

出版信息

Eur Arch Otorhinolaryngol. 2015 Apr;272(4):949-969. doi: 10.1007/s00405-014-3010-x. Epub 2014 Apr 3.

DOI:10.1007/s00405-014-3010-x
PMID:24695941
Abstract

In contrast to total or extracapsular tonsillectomy (TE), subtotal/intracapsular/partial tonsillectomy (SIPT) or tonsillotomy (TT) is associated with significant less postoperative morbidity. It has been stated that patients older than 8 years of age or with a history of tonsillitis should be excluded from SIPT/TT. Some health insurance companies mandate utilization of particular surgical instruments. Finally, it has been stated that the remaining tonsillar tissue may become a subject of recurrent tonsillitis or tonsillar regrowth, in both cases requiring revision surgery in terms of TE. This literature review was undertaken to clarify what has been validated in the literature concerning indications, surgical techniques, complications and outcome of SIPT/TT as reported since 1960. A Medline review was undertaken and all papers included that were published in English or German language until September 30, 2013. Exclusion criteria were: publication date 1960 and earlier, other languages, no relation to tonsil surgery, papers not available to the authors, uncommon surgical techniques, national surveys or studies without patients. The quality of the papers was classified according to "The Oxford 2011 Levels of Evidence". The surgical techniques were classified according to Windfuhr and Werner and extended to interstitial tonsil therapy. Other issues were: study period, hemorrhage, dehydration, intake of analgesics, return to normal diet, surgical instruments, operation time, number of surgeons involved, number of patients, age, indications, follow-up, rate of tonsillar regrowth, tonsillitis and secondary TE. A total of 379 different publications were retrieved, but only 86 studies found eligible for further analysis. There were 10,499 patients in the study groups and 10,448 patients in the control groups. Utilization of the microdebrider largely prevailed, followed by Coblation, CO2-LASER, surgical scissor, Radiofrequency, Interstitial ThermoTherapy with various instruments, Diode-LASER, and other instruments. Instruments were not specified for 1,815 patients. Data for operation time, intraoperative bleeding, return to normal diet, analgesic intake were in favor for SIPT/TT and ablation procedures. Regrowth and tonsillitis occurred in rates of <6 % on average. Secondary surgery became necessary in only every third patient of this subgroup. Studies of variable quality impede comparison of all aspects in the papers. At least every second study did not address issues like operation time, intraoperative bleeding, return to normal diet, analgesic intake, rates of tonsillar regrowth, postsurgical tonsillitis and secondary TE. There are insufficient data to show that a single surgical instrument is superior. A history of tonsillitis and an age >8 years are definitely not commonly accepted as contraindication for SIPT, TT or ablation procedures. There is a strong evidence that pain is less after SIPT, TT and tonsil ablation resulting in an earlier return to normal diet and activity. Large, well-designed randomized controlled trials with an adequate follow-up are necessary to determine whether the procedure is capable to replace TE to resolve upper airway obstruction resulting from tonsillar hypertrophy as well as recurrent episodes of tonsillitis in children and adults.

摘要

与全扁桃体切除术或扁桃体包膜外切除术(TE)相比,次全/扁桃体包膜内/部分扁桃体切除术(SIPT)或扁桃体切开术(TT)术后的发病率明显较低。有人指出,8岁以上或有扁桃体炎病史的患者不应接受SIPT/TT。一些健康保险公司规定要使用特定的手术器械。最后,有人指出,剩余的扁桃体组织可能会成为复发性扁桃体炎或扁桃体再生的病灶,在这两种情况下都需要进行TE方面的翻修手术。进行这项文献综述是为了阐明自1960年以来文献中关于SIPT/TT的适应证、手术技术、并发症和结果的已验证内容。对Medline进行了检索,纳入了截至2013年9月30日以英文或德文发表的所有论文。排除标准为:出版日期在1960年及以前、其他语言、与扁桃体手术无关、作者无法获取的论文、不常见的手术技术、全国性调查或无患者的研究。根据“牛津2011证据水平”对论文质量进行分类。手术技术根据Windfuhr和Werner进行分类,并扩展到间质扁桃体治疗。其他问题包括:研究时期、出血、脱水、镇痛药的使用、恢复正常饮食、手术器械、手术时间、参与手术的外科医生数量、患者数量、年龄、适应证、随访、扁桃体再生率、扁桃体炎和二次TE。共检索到379篇不同的出版物,但只有86项研究符合进一步分析的条件。研究组有10499例患者,对照组有10448例患者。微型切割器的使用最为普遍,其次是低温等离子消融、二氧化碳激光、手术剪刀、射频、使用各种器械的间质热疗、二极管激光和其他器械。1815例患者未指明使用的器械。手术时间、术中出血、恢复正常饮食、镇痛药使用的数据有利于SIPT/TT和消融手术。再生和扁桃体炎的平均发生率<6%。在该亚组中,仅每第三位患者需要进行二次手术。质量参差不齐的研究妨碍了对论文各方面的比较。至少每隔一项研究未涉及手术时间、术中出血、恢复正常饮食、镇痛药使用、扁桃体再生率、术后扁桃体炎和二次TE等问题。没有足够的数据表明单一手术器械更具优势。扁桃体炎病史和年龄>8岁绝对不是SIPT、TT或消融手术普遍接受的禁忌证。有强有力的证据表明,SIPT、TT和扁桃体消融术后疼痛较轻,能使患者更早恢复正常饮食和活动。需要进行大型、设计良好且有充分随访的随机对照试验,以确定该手术是否能够替代TE来解决因扁桃体肥大以及儿童和成人复发性扁桃体炎导致的上呼吸道梗阻问题。

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