School of Environmental Science and Engineering Guangdong University of Technology, Guangzhou 510006, China.
School of Environmental Science and Engineering Guangdong University of Technology, Guangzhou 510006, China.
J Colloid Interface Sci. 2020 Jul 1;571:21-29. doi: 10.1016/j.jcis.2020.03.027. Epub 2020 Mar 9.
This work systematically investigated the effects of prepolymerization on the property of multi-templates surface molecularly imprinted polymer (MIP), which was utilized to quickly and simultaneously separate and detect six sulfonamides (sulfadiazine, sulfathiazole, sulfamerazine, sulfamethazine, sulfamethoxazole and sulfadoxine) in real waters. The MIPs were prepared using the six sulfonamides as the templates, mesoporous silica supported onto the surface of magnetic graphene oxide as the carrier and 4-vinylbenzoic as the functional monomer, with and without prepolymerization of templates with functional monomer. The preparation and adsorption conditions were optimized. It was found that the adsorption capacities of the selected six sulfonamides on the MIP (pre) prepared with prepolymerization were apparently higher than those on the MIP (no pre) synthesized without prepolymerization. Subsequently, the MIPs were utilized as adsorbents for SPE of these sulfonamides, and coupled with high performance liquid chromatography (HPLC) for the determination of sulfonamides. The developed analytical method showed outstanding applicability for the detection of trace sulfonamides in real water samples. The spiked recoveries and relative standard deviations (RSDs) of the six sulfonamides using MIP (no pre) and MIP (pre) were 73.34-99.43% and 87.37-102.34%, 2.28-7.77% and 3.18-6.49%, respectively.
这项工作系统地研究了预聚合对多模板表面分子印迹聚合物（MIP）性能的影响，该聚合物用于快速同时分离和检测实际水样中的六种磺胺类药物（磺胺嘧啶、磺胺噻唑、磺胺甲噁唑、磺胺二甲嘧啶、磺胺甲噁唑和磺胺多辛）。MIPs 是使用这六种磺胺类药物作为模板，介孔硅负载在磁性氧化石墨烯表面作为载体，4-乙烯基苯甲酸作为功能单体，有和没有模板与功能单体的预聚合来制备的。优化了制备和吸附条件。结果发现，具有预聚合的 MIP（pre）对选择的六种磺胺类药物的吸附容量明显高于没有预聚合的 MIP（no pre）合成的吸附容量。随后，将 MIP 用作这些磺胺类药物的 SPE 吸附剂，并与高效液相色谱（HPLC）结合用于检测磺胺类药物。所开发的分析方法对于检测实际水样中的痕量磺胺类药物具有出色的适用性。使用 MIP（no pre）和 MIP（pre）的六种磺胺类药物的加标回收率和相对标准偏差（RSD）分别为 73.34-99.43%和 87.37-102.34%，2.28-7.77%和 3.18-6.49%。
