Department of Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Int J Environ Res Public Health. 2020 Mar 9;17(5):1763. doi: 10.3390/ijerph17051763.
Although obesity is considered osteoprotective, the effects of body fat and fat distribution on bone tissue after adjusting for the effects of body weight remain uncertain. This study evaluated the relationships between fat mass, fat distribution, and bone mineral status beyond its weight-bearing effect. We recruited 466 children aged 6-10 years in China. Dual-energy X-ray absorptiometry was used to determine the bone mineral density (BMD) and bone mineral content (BMC) in the total body and total body less head (TBLH), as well as the fat mass (FM) and percentage fat mass (%FM) of the total and segmental body. Weight-adjusted measures of FM and %FM were derived using the residual method. After adjusting for the effects of covariates, we observed statistically significant, dose-dependent negative relationships between the TBLH·BMD/BMC and various weight-adjusted measures of body fat ( for trend: <0.001-0.038). For each standard deviation increment in the weight-adjusted total body, TBLH, trunk and limbs, the size-adjusted BMC decreased approximately 9.44, 9.28, 8.13, and 6.65 g in boys, respectively, and by approximately 13.74, 13.71, 7.84, and 12.95 g in girls, respectively. Significant inverse associations between FM accumulation in the total body and most body parts with the BMD/BMC were observed in both boys and girls after adjusting for weight and potential confounders.
虽然肥胖被认为对骨骼有保护作用，但在调整体重影响后，体脂肪量和脂肪分布对骨组织的影响仍不确定。本研究评估了脂肪量、脂肪分布与骨矿物质状态之间的关系，超出了其承重作用。我们在中国招募了 466 名 6-10 岁的儿童。使用双能 X 射线吸收法测量全身和全身（不包括头部）的骨矿物质密度（BMD）和骨矿物质含量（BMC），以及全身和各部位的脂肪量（FM）和体脂百分比（%FM）。使用残差法得出 FM 和 %FM 的体重校正测量值。在调整了协变量的影响后，我们观察到 TBLH·BMD/BMC 与各种体重校正体脂肪测量值之间存在统计学上显著的、剂量依赖性的负相关（趋势<0.001-0.038）。对于体重校正的全身、TBLH、躯干和四肢的每一个标准差增量，男孩的体型校正 BMC 分别减少了约 9.44、9.28、8.13 和 6.65 克，而女孩则分别减少了约 13.74、13.71、7.84 和 12.95 克。在调整体重和潜在混杂因素后，在男孩和女孩中，均观察到全身和大多数身体部位的 FM 积累与 BMD/BMC 呈显著负相关。
