Mao Xueqian, Jin Xueyi, Hu Ying, He Panpan, Yang Qianwen, Zhang Zhiwei, Jing Lipeng
Department of Epidemiology and Statistics, 12426 School of Public Health, Lanzhou University , Lanzhou, Gansu Province, China.
J Pediatr Endocrinol Metab. 2025 May 22. doi: 10.1515/jpem-2024-0600.
A prospective study was conducted examining the association between blood lipid levels and bone mineral density in preschool-aged children.
Healthy preschool-aged children (n=411) were included in this 12-month cohort study. The bone mineral density and bone mineral content of the non-dominant forearm and calcaneus were measured using dual-energy X-ray absorptiometry (DXA). Additionally, the children's fasting blood was drawn at baseline to measure blood lipids.
The sample comprised 411 healthy preschool-aged children, 208 girls and 203 boys, with a mean age of 4.80±0.70 years. After one year of observation, the bone mineral density of the non-dominant calcaneus in preschool children increased by 30.37 mg/cm, bone mineral content increased by 29.85 mg, and triglyceride levels increased by 0.05 mmol/L. A significant inverse assocation was observed between serum triglyceride levels within the normal physiological range and the changes in bone mineral density (BMD) at the non-dominant calcaneus in preschool children, whereas no such association was detected with BMD changes in the non-dominant forearm. A 1 mmol/L increase in triglycerides within the physiological normal range was associated with a 6.73 mg/cm decrease in bone mineral density (95 % CI: -12.90, -0.56) and a 5.98 mg decrease in bone mineral content (95 % CI: -11.77, -0.19). There was no significant relationship between other lipids and bone mineral density.
Serum triglyceride concentrations within the physiological normal range showed a significant negative correlation with the 12-month increment of calcaneal bone mineral density in preschool children (p<0.05).
开展一项前瞻性研究，探讨学龄前儿童血脂水平与骨密度之间的关联。
本12个月队列研究纳入了411名健康学龄前儿童。使用双能X线吸收法（DXA）测量非优势前臂和跟骨的骨密度和骨矿物质含量。此外，在基线时采集儿童空腹血样以检测血脂。
样本包括411名健康学龄前儿童，其中208名女孩和203名男孩，平均年龄为4.80±0.70岁。经过一年观察，学龄前儿童非优势跟骨的骨密度增加了30.37mg/cm，骨矿物质含量增加了29.85mg，甘油三酯水平增加了0.05mmol/L。在学龄前儿童正常生理范围内的血清甘油三酯水平与非优势跟骨骨密度（BMD）变化之间观察到显著负相关，而未检测到与非优势前臂BMD变化存在此类关联。生理正常范围内甘油三酯每增加1mmol/L，骨密度降低6.73mg/cm（95%CI：-12.90，-0.56），骨矿物质含量降低5.98mg（95%CI：-11.77，-0.19）。其他血脂与骨密度之间无显著关系。
生理正常范围内的血清甘油三酯浓度与学龄前儿童跟骨骨密度12个月的增量呈显著负相关（p<0.05）。
