Carvalho Cátia A, Broday Limor
Department of Cell and Developmental Biology, School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
J Dev Biol. 2020 Mar 9;8(1):7. doi: 10.3390/jdb8010007.
The versatility of epithelial cell structure is universally exploited by organisms in multiple contexts. Epithelial cells can establish diverse polarized axes within their tridimensional structure which enables them to flexibly communicate with their neighbors in a 360° range. Hence, these cells are central to multicellularity, and participate in diverse biological processes such as organismal development, growth or immune response and their misfunction ultimately impacts disease. During the development of an organism, the first task epidermal cells must complete is the formation of a continuous sheet, which initiates its own morphogenic process. In this review, we will focus on the embryonic epithelial morphogenesis. We will describe how its formation, maturation, and spatial arrangements set the final shape of the nematode . Special importance will be given to the tissue-tissue interactions, regulatory tissue-tissue feedback mechanisms and the players orchestrating the process.
上皮细胞结构的多功能性在多种情况下被生物体广泛利用。上皮细胞可以在其三维结构内建立不同的极化轴，这使它们能够在360°范围内与相邻细胞灵活通信。因此，这些细胞是多细胞性的核心，并参与多种生物过程，如生物体发育、生长或免疫反应，其功能失调最终会影响疾病。在生物体发育过程中，表皮细胞必须完成的首要任务是形成连续的薄片，这启动了其自身的形态发生过程。在这篇综述中，我们将重点关注胚胎上皮形态发生。我们将描述其形成、成熟和空间排列如何决定线虫的最终形状。将特别强调组织-组织相互作用、调节性组织-组织反馈机制以及协调这一过程的参与者。
