La Vignera Sandro, Cannarella Rossella, Condorelli Rosita A, Calogero Aldo E
Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
J Clin Med. 2020 Mar 13;9(3):780. doi: 10.3390/jcm9030780.
Male infertility is a widespread condition among western countries. Meta-regression data show that sperm concentration and total sperm count have halved in the last decades. The reasons of this decline are still unclear. The evaluation of testicular function in pre-pubertal children may be effective in the timely detection of Sertoli cell (SC) disfunction, which anticipates the diagnosis of male infertility. The aim of this Special Issue is to gather together in vitro evidence on SC physiology, causes of SC dysfunction, and to suggest a practical approach to be adopted in children.
男性不育在西方国家是一种普遍存在的病症。Meta回归数据显示，在过去几十年中，精子浓度和精子总数减半。这种下降的原因仍不清楚。对青春期前儿童的睾丸功能进行评估可能有助于及时发现支持细胞（SC）功能障碍，这比男性不育的诊断要早。本期特刊的目的是收集关于支持细胞生理学、支持细胞功能障碍原因的体外证据，并提出一种适用于儿童的实用方法。
