Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Department of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South Africa.
Molecules. 2020 Mar 13;25(6):1316. doi: 10.3390/molecules25061316.
Malaria, affecting all continents, remains one of the life-threatening diseases introduced by parasites that are transmitted to humans through the bites of infected mosquitoes. Although insecticides are currently used to reduce malaria transmission, their safety concern for living systems, as well as the environment, is a growing problem. Therefore, the discovery of novel, less toxic, and environmentally safe molecules to effectively combat the control of these vectors is in high demand. In order to identify new potential larvicidal agents, a series of 2-aryl-1,2-dihydroquinazolin-4-one derivatives were synthesized and evaluated for their larvicidal activity against . The in silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the compounds were also investigated and most of the derivatives possessed a favorable ADMET profile. Computational modeling studies of the title compounds demonstrated a favorable binding interaction against the acetylcholinesterase enzyme molecular target. Thus, 2-aryl-1,2-dihydroquinazolin-4-ones were identified as a novel class of insecticides which can be used as lead molecules for the further development of more potent and safer larvicidal agents for treating malaria.
疟疾影响所有大陆，仍然是由寄生虫引起的威胁生命的疾病之一，寄生虫通过受感染的蚊子叮咬传播给人类。尽管目前使用杀虫剂来减少疟疾的传播，但它们对生物系统和环境的安全性问题日益严重。因此，需要发现新型的、毒性更低且对环境安全的分子，以有效控制这些传播媒介。为了鉴定新的潜在杀幼虫剂，合成了一系列 2-芳基-1,2-二氢喹唑啉-4-酮衍生物，并评估了它们对 的杀幼虫活性。还研究了化合物的体内吸收、分布、代谢、排泄和毒性（ADMET）性质，大多数衍生物具有良好的 ADMET 特征。标题化合物的计算建模研究表明，它们与乙酰胆碱酯酶酶分子靶标具有良好的结合相互作用。因此，2-芳基-1,2-二氢喹唑啉-4-酮被确定为一类新型杀虫剂，可作为进一步开发更有效和更安全的杀幼虫剂来治疗疟疾的先导分子。
