用于液相间分离技术的有机聚合物整体柱的后聚合功能化的各种策略。

Various Strategies in Post-Polymerization Functionalization of Organic Polymer-Based Monoliths Used in Liquid Phase Separation Techniques.

机构信息

Department of Chemistry, Taif University, Taif 21944, Saudi Arabia.

Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, USA.

出版信息

Molecules. 2020 Mar 13;25(6):1323. doi: 10.3390/molecules25061323.

This review article is aimed at summarizing the various strategies that have been developed so far for post-polymerization functionalization (PPF) of organic polymer-based monoliths used in liquid phase separation techniques, namely HPLC at all scales and capillary electrochromatography (CEC). The reader will find the organic reactions performed on monolithic columns for grafting the chromatographic ligands needed for solving the separation problems on hand. This process involves therefore the fabrication of template monoliths that carry reactive functional groups to which chromatographic ligands can be covalently attached in a post-polymerization kind of approach. That is, the template monolith that has been optimized in terms of pore structure and other morphology can be readily modified and tailor made on column to fit a particular separation. The review article will not only cover the various strategies developed so far but also describe their separation applications. To the best of our knowledge, this review article will be the first of its kind.

这篇综述文章旨在总结迄今为止为用于液相分离技术的有机聚合物整体柱的后聚合功能化（PPF）开发的各种策略，即各种规模的高效液相色谱（HPLC）和胶束电动色谱（MEKC）。读者将了解在整体柱上进行的有机反应，这些反应用于接枝解决手头分离问题所需的色谱配体。因此，该过程涉及制造带有反应性官能团的模板整体柱，这些官能团可以通过后聚合的方式共价连接色谱配体。也就是说，可以对经过优化的具有孔结构和其他形态的模板整体柱进行快速修饰和柱上定制，以适应特定的分离。这篇综述文章不仅将涵盖迄今为止开发的各种策略，还将描述它们的分离应用。据我们所知，这篇综述文章将是此类文章中的第一篇。