Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
J Chromatogr A. 2018 Nov 30;1578:99-105. doi: 10.1016/j.chroma.2018.10.008. Epub 2018 Oct 10.
A novel ionic liquid (1-allyl-methylimidazolium chloride, AlMeImCl) polymer monolith poly(ionic liquid-co-ethylene dimethacrylate) incorporated with zeolitic imidazolate framework-8 (ZIF-8-poly(IL-co-EDMA)) was firstly synthesized as stationary phases of monolithic column for capillary electrochromatography by one-step copolymerization. Incorporation of ZIF-8 into ionic liquid polymer monolith evidently enhanced the separation selectivity for four alkylbenzenes in reversed phase capillary electrochromatography (CEC), due to the synergistic effect derived from the same imidazole ring structure of ionic liquid and organic ligands of ZIF-8. Meanwhile, electroosmotic flow (EOF) was generated by ionic liquid in a wide range of pH values from 2.0 to 12.0. The resultant monolithic columns were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR). The results indicated that the prepared monolithic columns had good permeability and mechanism stability. The resultant monolithic columns were applied for the separation of neutral compounds, anilines and phenols. The highest column efficiency was 2.07 × 10 plates m (theoretical plates, N) for toluene. Under optimal conditions, reproducibility was obtained with relative standard deviations (RSDs) of the retention time for run-to-run, day-to-day, column-to-column and batch-to-batch were in the range of 1.58 - 3.19%, 1.92 - 3.87%, 3.84 - 4.96% and 2.63 - 4.33%, respectively. Incorporation ZIF-8 into ionic liquid polymer monolith was a promising way for the application of new materials in the fabrication of novel monolithic columns.
一种新型离子液体（1-烯丙基-甲基咪唑氯，AlMeImCl）聚合物整体柱聚（离子液体-共-乙二醇二甲基丙烯酸酯）与沸石咪唑酯骨架-8（ZIF-8-聚（IL-co-EDMA））相结合，首次通过一步共聚法合成作为毛细管电色谱的固定相。ZIF-8 掺入离子液体聚合物整体柱中，由于离子液体和 ZIF-8 的有机配体具有相同的咪唑环结构，协同作用明显增强了反相毛细管电色谱（CEC）中对四种烷基苯的分离选择性。同时，在 pH 值为 2.0 至 12.0 的宽范围内产生电渗流（EOF）。通过扫描电子显微镜（SEM）和傅里叶变换红外（FT-IR）对所得整体柱进行了表征。结果表明，所制备的整体柱具有良好的渗透性和机制稳定性。将所得整体柱用于分离中性化合物、苯胺和苯酚。甲苯的最高柱效为 2.07 × 10 板 m（理论板，N）。在最佳条件下，保留时间的相对标准偏差（RSD）在运行间、日间、柱间和批间分别为 1.58-3.19%、1.92-3.87%、3.84-4.96%和 2.63-4.33%。将 ZIF-8 掺入离子液体聚合物整体柱中是在新型整体柱制备中应用新材料的一种有前途的方法。
