长链非编码RNA在HIV-1调控中的作用机制及新型治疗靶点的鉴定
Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets.
作者信息
Ray Roslyn M, Morris Kevin V
机构信息
The Center for Gene Therapy, The Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA.
出版信息
Noncoding RNA. 2020 Mar 13;6(1):12. doi: 10.3390/ncrna6010012.
Abstract
This review aims to highlight the role of long non-coding RNAs in mediating human immunodeficiency virus (HIV-1) viral replication, latency, disease susceptibility and progression. In particular, we focus on identifying possible lncRNA targets and their purported mechanisms of action for future drug design or gene therapeutics.
摘要
本综述旨在强调长链非编码RNA在介导人类免疫缺陷病毒（HIV-1）病毒复制、潜伏、疾病易感性及进展方面的作用。特别地，我们着重于识别潜在的lncRNA靶点及其假定的作用机制，以期用于未来的药物设计或基因治疗。
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