Doghman-Bouguerra Mabrouka, Finetti Pascal, Durand Nelly, Parise Ivy Zortéa S, Sbiera Silviu, Cantini Giulia, Canu Letizia, Hescot Ségolène, Figueiredo Mirna M O, Komechen Heloisa, Sbiera Iuliu, Nesi Gabriella, Paci Angelo, Al Ghuzlan Abir, Birnbaum Daniel, Baudin Eric, Luconi Michaela, Fassnacht Martin, Figueiredo Bonald C, Bertucci François, Lalli Enzo
Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur, CNRS, 660 route des Lucioles-Sophia Antipolis, 06560 Valbonne, France.
NEOGENEX-CANCER CNRS International Associated Laboratory, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France; 1532 Av. Silva Jardim, Curitiba PR 80250-200, Brazil.
Cancers (Basel). 2020 Mar 14;12(3):689. doi: 10.3390/cancers12030689.
The SF-1 transcription factor target gene encodes a cancer-testis antigen that has an important role in regulating apoptosis and response to chemotherapy in adrenocortical carcinoma (ACC) cells. Autoantibodies directed against FATE1 were previously detected in patients with hepatocellular carcinoma. In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, expression is a robust prognostic indicator in adult patients with ACC and is associated with increased steroidogenic and decreased immune response gene expression. These data can open perspectives for novel strategies in ACC immunotherapy.
SF-1转录因子靶基因编码一种癌-睾丸抗原，该抗原在调节肾上腺皮质癌（ACC）细胞的凋亡和化疗反应中起重要作用。先前在肝细胞癌患者中检测到针对FATE1的自身抗体。在本研究中，我们使用三种不同方法（免疫荧光、酶联免疫吸附测定和蛋白质印迹法）调查了儿童和成人肾上腺皮质肿瘤患者循环抗FATE1抗体的流行情况。我们的结果表明，这些患者中存在普遍的抗FATE1免疫反应。此外，FATE1表达是成年ACC患者强有力的预后指标，且与类固醇生成增加和免疫反应基因表达降低相关。这些数据可为ACC免疫治疗的新策略开辟前景。
