Department of Pediatric Neurology and Pediatrics, St. Queen Jadwiga's Regional Clinical Hospital No 2 Rzeszów, 35-301 Rzeszów, Poland.
Department of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Int J Environ Res Public Health. 2020 Mar 15;17(6):1916. doi: 10.3390/ijerph17061916.
Melatonin plays an important role in regulating the sleep-wake cycle and adaptation to environmental changes. Concentration measurements in bioliquids such as serum/plasma, saliva and urine are widely used to assess peripheral rhythm. The aim of the study was to compare methods and conditions of determinations carried out with the identification of factors potentially affecting the measurements obtained. We have identified a group of modifiable and unmodifiable factors that facilitate data interpretation. Knowledge of modifiers allows you to carefully plan the test protocol and then compare the results. There is no one universal sampling standard, because the choice of method and biofluid depends on the purpose of the study and the research group.
褪黑素在调节睡眠-觉醒周期和适应环境变化方面起着重要作用。生物液体（如血清/血浆、唾液和尿液）中的浓度测量被广泛用于评估外周节律。本研究的目的是比较不同的方法和条件，并确定可能影响测量结果的因素。我们已经确定了一组可改变和不可改变的因素，这些因素有助于解释数据。了解这些修饰因子可以帮助您仔细规划测试方案，然后比较结果。没有一个通用的采样标准，因为方法和生物液体的选择取决于研究目的和研究小组。
