Department of General Practice, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Curr Alzheimer Res. 2020;17(2):105-111. doi: 10.2174/1567205017666200317102337.
Previous case-control studies have focused on the relationship between ALDH2 gene polymorphism and late-onset Alzheimer's Disease (LOAD), but no definite unified conclusion has been reached. Therefore, the correlation between ALDH2 Glu504Lys polymorphism and LOAD remains controversial. To analyze the correlation between ALDH2 polymorphism and the risk of LOAD, we implemented this up-to-date meta-analysis to assess the probable association.
Studies were searched through China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals, China Biology Medicine, PubMed, Cochrane Library, Clinical- Trials.gov, Embase, and MEDLINE from January 1, 1994 to December 31, 2018, without any restrictions on language and ethnicity.
Five studies of 1057 LOAD patients and 1136 healthy controls met our criteria for the analysis. Statistically, the ALDH2 GA/AA genotype was not linked with raising LOAD risk (odds ratio (OR) = 1.48, 95% confidence interval (CI) = 0.96-2.28, p = 0.07). In subgroup analysis, the phenomenon that men with ALDH2*2 had higher risk for LOAD (OR = 1.72, 95%CI = 1.10-2.67, p = 0.02) was observed.
This study comprehends only five existing case-control studies and the result is negative. The positive trend might appear when the sample size is enlarged. In the future, more large-scale casecontrol or cohort studies should be done to enhance the association between ALDH2 polymorphism and AD or other neurodegenerative diseases.
先前的病例对照研究主要集中在 ALDH2 基因多态性与迟发性阿尔茨海默病（LOAD）之间的关系上，但尚未得出明确的统一结论。因此，ALDH2Glu504Lys 多态性与 LOAD 之间的相关性仍存在争议。为了分析 ALDH2 多态性与 LOAD 风险之间的相关性，我们进行了这项最新的荟萃分析，以评估可能的相关性。
通过中国知网（CNKI）、维普数据库、中国生物医学文献数据库、PubMed、Cochrane 图书馆、Clinical-Trials.gov、Embase 和 MEDLINE 检索 1994 年 1 月 1 日至 2018 年 12 月 31 日的研究，不限制语言和种族。
符合纳入标准的病例对照研究共 5 项，纳入 LOAD 患者 1057 例，健康对照 1136 例。统计分析显示，ALDH2GA/AA 基因型与 LOAD 发病风险增加无关（比值比（OR）=1.48，95%置信区间（CI）=0.96-2.28，p=0.07）。亚组分析显示，男性携带 ALDH2*2 时 LOAD 发病风险更高（OR=1.72，95%CI=1.10-2.67，p=0.02）。
本研究仅纳入了 5 项现有的病例对照研究，结果为阴性。当样本量增大时，可能会出现阳性趋势。未来需要更多大规模的病例对照或队列研究来增强 ALDH2 多态性与 AD 或其他神经退行性疾病之间的关联。
