自然杀伤 T 细胞淋巴瘤的基因组和转录组特征。

Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma.

机构信息

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China.

出版信息

Cancer Cell. 2020 Mar 16;37(3):403-419.e6. doi: 10.1016/j.ccell.2020.02.005.

DOI:10.1016/j.ccell.2020.02.005

PMID:32183952

Abstract

Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes of NKTCL based on genomic structural alterations and EBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosed NKTCL and defined three prominent subtypes, which differ significantly in cell of origin, EBV gene expression, transcriptional signatures, and responses to asparaginase-based regimens and targeted therapy. Our findings thus identify molecular networks of EBV-associated pathogenesis and suggest potential clinical strategies on NKTCL.

摘要

自然杀伤/T 细胞淋巴瘤（NKTCL）是一种侵袭性和异质性的非霍奇金淋巴瘤，与 EBV 感染密切相关。为了根据基因组结构改变和 EBV 序列鉴定 NKTCL 的分子亚型，我们对 128 例新诊断的 NKTCL 活检样本进行了多组学研究，定义了三种主要的亚型，它们在起源细胞、EBV 基因表达、转录特征以及对天冬酰胺酶为基础的方案和靶向治疗的反应方面存在显著差异。我们的研究结果因此确定了 EBV 相关发病机制的分子网络，并为 NKTCL 提出了潜在的临床策略。