Feng Zhi-ying, Mo Xiang-lan, Shao Chun-Kui, Su Zu-lan
Department of Pathology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2007 Sep;27(9):1338-40.
To investigate the expression of matrix metalloproteinase 9 (MMP9) in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus (EBV) infection.
The expression of MMP9 and EBV-encoded RNA (EBER) were detected by immunohistochemistry and in situ hybridization in 59 cases of mucosal natural killer/T cell and mature T cell lymphomas.
The positivity rates of MMP9 and EBERs were 83.05% and 72.88% respectively. The positivity rate of EBERs was correlated with histopathological subtype (P<0.05), but not with clinical stage, vascular invasion or the patients' survival time (P>0.05). The expression level of MMP9 was not correlated with the clinical stage, vascular invasion or survival time (P>0.05). No significant correlation was found between MMP9 expression and EBV infection.
EBV may play an important role in the development of mucosal natural killer/T cell and mature T cell lymphomas and promote disease progression by up-regulating MMP9 expression indirectly. Elimination of EBV infection may be helpful to prevent the development of lymphoma.
探讨基质金属蛋白酶9（MMP9）在黏膜自然杀伤/T细胞及成熟T细胞淋巴瘤中的表达及其与EB病毒（EBV）感染的关系。
采用免疫组织化学和原位杂交技术检测59例黏膜自然杀伤/T细胞及成熟T细胞淋巴瘤中MMP9和EBV编码RNA（EBER）的表达。
MMP9和EBERs的阳性率分别为83.05%和72.88%。EBERs的阳性率与组织病理学亚型相关（P<0.05），但与临床分期、血管侵犯或患者生存时间无关（P>0.05）。MMP9的表达水平与临床分期、血管侵犯或生存时间无关（P>0.05）。MMP9表达与EBV感染之间未发现显著相关性。
EBV可能在黏膜自然杀伤/T细胞及成熟T细胞淋巴瘤的发生发展中起重要作用，并通过间接上调MMP9表达促进疾病进展。消除EBV感染可能有助于预防淋巴瘤的发生。
Zotero 插件