硒和维生素E治疗杜氏肌营养不良症：对肌肉功能无影响。

Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function.

作者信息

Bäckman E, Nylander E, Johansson I, Henriksson K G, Tagesson C

机构信息

Department of Neurophysiology, University Hospital, Linköping, Sweden.

出版信息

Acta Neurol Scand. 1988 Nov;78(5):429-35. doi: 10.1111/j.1600-0404.1988.tb03681.x.

DOI:10.1111/j.1600-0404.1988.tb03681.x

PMID:3218450

Abstract

16 boys with Duchenne muscular dystrophy (DMD) were treated with sodium selenite and vitamin E for one year. One group of patients (10 boys) was examined using a battery of tests to assess muscular strength and function and cardiopulmonary function, and by CT scanning of 2 muscle groups over the 4 years prior to treatment. Six boys with DMD entered the study when the treatment was begun. Tests of muscular force and function, cardiopulmonary tests and CT-scanning were performed at the onset of treatment, and after 6 and 12 months. No beneficial effect on either muscular force or function was found during the treatment period. It is concluded that selenium and vitamin E in high doses do not improve muscle function in DMD.

摘要

16名患有杜氏肌营养不良症（DMD）的男孩接受了亚硒酸钠和维生素E治疗，为期一年。一组患者（10名男孩）在治疗前的4年里通过一系列测试来评估肌肉力量和功能以及心肺功能，并对两组肌肉进行CT扫描。6名患有DMD的男孩在治疗开始时进入研究。在治疗开始时、6个月和12个月后进行了肌肉力量和功能测试、心肺测试以及CT扫描。在治疗期间未发现对肌肉力量或功能有任何有益影响。得出的结论是，高剂量的硒和维生素E并不能改善DMD患者的肌肉功能。