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对患有肌肉萎缩症男孩进行的硒和维生素E试验。

A trial of selenium and vitamin E in boys with muscular dystrophy.

作者信息

Gamstorp I, Gustavson K H, Hellström O, Nordgren B

出版信息

J Child Neurol. 1986 Jul;1(3):211-4. doi: 10.1177/088307388600100306.

DOI:10.1177/088307388600100306
PMID:3298399
Abstract

The administration of selenium and vitamin E was tried in a group of 20 boys with muscular dystrophy. Muscular strength was measured at intervals of 6 months. The boys were treated for 1 year (selenium 6 micrograms/kg for 6 months and 20 micrograms/kg for 6 months), followed by 1 year of no treatment. The whole series was completed in 16 boys, nine of whom had classical Duchenne muscular dystrophy and the rest who had more benign variants. No boy showed any side effects. The decrease of muscle strength was slightly more rapid during the second year (no treatment) than during the first year (with treatment) of the trial. The difference was, however, slight and could conceivably be explained by the increase of age. No boy showed any practically usable increase of muscle strength during the year of treatment. The minimal muscle strength required for walking is presented.

摘要

对一组20名患有肌肉萎缩症的男孩试用了硒和维生素E。每隔6个月测量一次肌肉力量。这些男孩接受了1年的治疗(硒的剂量为6微克/千克,持续6个月,然后为20微克/千克,持续6个月),随后是1年的未治疗期。整个系列研究共有16名男孩完成,其中9名患有典型的杜氏肌肉萎缩症,其余患有症状较轻的变异型。没有男孩出现任何副作用。在试验的第二年(未治疗),肌肉力量的下降比第一年(治疗期间)略快。然而,差异很小,可以想象这是由年龄增长所导致的。在治疗的这一年里,没有男孩的肌肉力量出现任何实际可用的增加。文中还给出了行走所需的最小肌肉力量。

相似文献

1
A trial of selenium and vitamin E in boys with muscular dystrophy.对患有肌肉萎缩症男孩进行的硒和维生素E试验。
J Child Neurol. 1986 Jul;1(3):211-4. doi: 10.1177/088307388600100306.
2
Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function.硒和维生素E治疗杜氏肌营养不良症:对肌肉功能无影响。
Acta Neurol Scand. 1988 Nov;78(5):429-35. doi: 10.1111/j.1600-0404.1988.tb03681.x.
3
Systolic time intervals in patients with progressive muscular dystrophy treated with sodium selenite and vitamin E.用亚硒酸钠和维生素E治疗的进行性肌营养不良患者的收缩期时间间期
Med Biol. 1984;62(2):154.
4
Clinical investigation in Duchenne muscular dystrophy: penicillamine and vitamin E.
Muscle Nerve. 1988 Nov;11(11):1164-8. doi: 10.1002/mus.880111110.
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Selenium supplementation in X-linked muscular dystrophy. Effects on erythrocyte and serum selenium and on erythrocyte glutathione peroxidase activity.
Acta Paediatr Scand. 1985 Nov;74(6):886-90. doi: 10.1111/j.1651-2227.1985.tb10053.x.
6
[Selenium and vitamin E in patients with progressive muscular dystrophy].[进行性肌营养不良患者中的硒与维生素E]
Ann Pediatr (Paris). 1990 Jun;37(6):377-9.
7
Effects of selenium and vitamin E on muscular strength and blood parameters in Steinert disease.硒和维生素E对强直性肌营养不良症患者肌肉力量及血液参数的影响
Ital J Neurol Sci. 1990 Feb;11(1):37-42. doi: 10.1007/BF02334903.
8
Selenium metabolism and supplementation in patients with muscular dystrophy.
Neurology. 1989 May;39(5):655-9. doi: 10.1212/wnl.39.5.655.
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Long-term electrical stimulation of muscles in children with Duchenne and Becker muscular dystrophy.对杜氏和贝克氏肌肉营养不良症患儿肌肉进行长期电刺激。
Muscle Nerve. 1992 Mar;15(3):362-7. doi: 10.1002/mus.880150316.
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Beneficial and ineffective levels of selenium for growth and muscular dystrophy.对生长和肌肉萎缩症有益及无效的硒水平。
Br J Nutr. 1968 Dec;22(4):645-50. doi: 10.1079/bjn19680075.

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Duchenne Muscular Dystrophy.
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Effects of selenium and vitamin E on muscular strength and blood parameters in Steinert disease.硒和维生素E对强直性肌营养不良症患者肌肉力量及血液参数的影响
Ital J Neurol Sci. 1990 Feb;11(1):37-42. doi: 10.1007/BF02334903.