对患有肌肉萎缩症男孩进行的硒和维生素E试验。
A trial of selenium and vitamin E in boys with muscular dystrophy.
作者信息
Gamstorp I, Gustavson K H, Hellström O, Nordgren B
出版信息
J Child Neurol. 1986 Jul;1(3):211-4. doi: 10.1177/088307388600100306.
The administration of selenium and vitamin E was tried in a group of 20 boys with muscular dystrophy. Muscular strength was measured at intervals of 6 months. The boys were treated for 1 year (selenium 6 micrograms/kg for 6 months and 20 micrograms/kg for 6 months), followed by 1 year of no treatment. The whole series was completed in 16 boys, nine of whom had classical Duchenne muscular dystrophy and the rest who had more benign variants. No boy showed any side effects. The decrease of muscle strength was slightly more rapid during the second year (no treatment) than during the first year (with treatment) of the trial. The difference was, however, slight and could conceivably be explained by the increase of age. No boy showed any practically usable increase of muscle strength during the year of treatment. The minimal muscle strength required for walking is presented.
对一组20名患有肌肉萎缩症的男孩试用了硒和维生素E。每隔6个月测量一次肌肉力量。这些男孩接受了1年的治疗（硒的剂量为6微克/千克，持续6个月，然后为20微克/千克，持续6个月），随后是1年的未治疗期。整个系列研究共有16名男孩完成，其中9名患有典型的杜氏肌肉萎缩症，其余患有症状较轻的变异型。没有男孩出现任何副作用。在试验的第二年（未治疗），肌肉力量的下降比第一年（治疗期间）略快。然而，差异很小，可以想象这是由年龄增长所导致的。在治疗的这一年里，没有男孩的肌肉力量出现任何实际可用的增加。文中还给出了行走所需的最小肌肉力量。
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